显微镜下的乳糜泻：组织学诊断特征和混杂因素。

Coeliac disease under a microscope: Histological diagnostic features and confounding factors.

机构信息

Internal Medicine and, Gastroenterology and Hepatic Diseases Unit, IRCCS Fondazione Policlinico Universitario A. Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.

出版信息

Comput Biol Med. 2019 Jan;104:335-338. doi: 10.1016/j.compbiomed.2018.10.020. Epub 2018 Oct 19.

DOI:10.1016/j.compbiomed.2018.10.020

PMID:30409469

Abstract

Coeliac disease (CD) and gluten-related disorders represent an important cornerstone of the daily practice of gastroenterologists, endoscopists and dedicated histopathologists. Despite the knowledge of clinical, serological and histological typical lesions, there are some conditions to consider for differential diagnosis. From the first description of histology of CD, several studies were conducted to define similar findings suggestive for microscopic enteritis. Considering the establishment of early precursor lesions, the imbalance of gut microbiota is another point still requiring a detailed definition. This review assesses the importance of a right overview in case of suspected gluten-related disorders and the several conditions mimicking a similar histology.

摘要

乳糜泻（CD）和与麸质相关的疾病是胃肠病学家、内镜医生和专门的组织病理学家日常实践的重要基石。尽管了解了临床、血清学和组织学的典型病变，但仍需要考虑一些鉴别诊断的情况。从 CD 的组织学的首次描述开始，就进行了多项研究以定义类似的微观肠炎表现。考虑到早期前体病变的建立，肠道微生物组的失衡是另一个仍需要详细定义的问题。本综述评估了在疑似与麸质相关的疾病和类似组织学的几种情况下正确全面评估的重要性。