急性心肌梗死（AMI）患者的硫醇二硫化物稳态
Thiol disulphide homeostasis in patients with acute myocardial infarction (AMI).
作者信息
Kavakli Havva Sahin, Sezer Ahmet Ali, Yilmaz Hidir, Koptur Pinar, Arslan Ulku, Akman Cem, Karakus Mustafa, Erel Ozcan, Bicer Cemile Koca, Ozbek Betul, Ethemoglu FilizBanu, Uncugil CenkFirat
机构信息
Emergency Department, Yildirim Beyazit University Yenimahalle Education and Research Hospital, Ankara.
Biochemistry Department, Ankara Ataturk Education and Research Hospital, Ankara, Turkey.
出版信息
J Pak Med Assoc. 2018 Nov;68(11):1631-1635.
OBJECTIVE
To investigate novel oxidative stress marker thiol disulphide homeostasis in patients with acute myocardial infarction..
METHODS
The case-control study was conducted at Yildirim Beyazit University, Ankara, Turkey, between October 26, 2015 and January 26, 2016. It comprised patients of ST elevation myocardial infarction, and healthy individuals. Troponin levels, native thiol, total thiol, and disulphide were compared among the groups. Results: Of the 128 subjects, 98(76.5%) were patients and 30(23.43%) were controls. Disulphide levels were lower in the patients compared to the controls (p<0.001).As troponin levels increased, native thiol, total thiol and disulphide levels in patients decreased (p<0.05).
RESULTS
Of the 128 subjects, 98(76.5%) were patients and 30(23.43%) were controls. Disulphide levels were lower in the patients compared to the controls (p<0.001).As troponin levels increased, native thiol, total thiol and disulphide levels in patients decreased (p<0.05).
CONCLUSIONS
Native thiol and total thiol levels may be used as a novel oxidative stres marker in patients with acute myocardial infarction.
目的
研究急性心肌梗死患者新型氧化应激标志物硫醇二硫化物稳态。
方法
病例对照研究于2015年10月26日至2016年1月26日在土耳其安卡拉的耶迪特佩大学进行。研究对象包括ST段抬高型心肌梗死患者和健康个体。比较各组肌钙蛋白水平、天然硫醇、总硫醇和二硫化物水平。结果：128名受试者中，98名（76.5%）为患者，30名（23.43%）为对照。患者的二硫化物水平低于对照组（p<0.001）。随着肌钙蛋白水平升高，患者的天然硫醇、总硫醇和二硫化物水平降低（p<0.05）。
结果
128名受试者中，98名（76.5%）为患者，30名（23.43%）为对照。患者的二硫化物水平低于对照组（p<0.001）。随着肌钙蛋白水平升高，患者的天然硫醇、总硫醇和二硫化物水平降低（p<0.05）。
结论
天然硫醇和总硫醇水平可作为急性心肌梗死患者新型氧化应激标志物。
Zotero 插件