从尿液中分离出的产ESBL/MBL大肠杆菌菌株的患病率、抗生素敏感性及表型筛选；巴基斯坦开伯尔-普赫图赫瓦省斯瓦比地区
Prevalence, antibiotic sensitivity and phenotypic screening of ESBL/MBL producer E. coli strains isolated from urine; District Swabi, KP, Pakistan.
作者信息
Jamil Johar, Haroon Muhammad, Sultan Ambareen, Khan Muhammad Atif, Gul Naima
机构信息
Department of Microbiology, University of Swabi, Swabi, Pakistan.
出版信息
J Pak Med Assoc. 2018 Nov;68(11):1704-1707.
The study aimed to record the prevalence of Urinary Tract Infection caused by E. coli, its antibiotic sensitivity and phenotypic detection of ESBL and MBL producer E. coli. Total of 240 urine samples were collected from Bacha Khan medical complex, Swabi. Antibiotic sensitivity and production of ESBL and MBL according to CLSI guidelines 2017 were performed. Out of 75 E. coli strains, only 25 (33.3%) isolates were positive for ESBL. Similarly, 25 were resistant to Imipenem, in which 12 (16%) isolates were positive for MBL production. E. coli isolates were found more sensitive to Amikacin 57 (76%) followed by Imipenem 50 (66.67%), Ofloxacin 48 (64%), Ciprofloxacin 44 (58.67%), Norfloxacin 42 (56%) and were 100% resistant to Penicillin, Ceftriaxone, Ceftazidime and Cefotaxime. The current study recorded the prevalence rate of UTI caused by E. coli was 75( 66.96%) and ccurrence rate of ESBL and MBL producers in the total (n=75) E. coli isolates was 25( 33.3%) and 12(48%) respectively.
该研究旨在记录由大肠杆菌引起的尿路感染的患病率、其抗生素敏感性以及产超广谱β-内酰胺酶（ESBL）和金属β-内酰胺酶（MBL）的大肠杆菌的表型检测。从斯瓦比的巴赫阿·汗医疗中心总共收集了240份尿液样本。根据2017年临床和实验室标准协会（CLSI）指南进行抗生素敏感性以及ESBL和MBL的检测。在75株大肠杆菌菌株中，只有25株（33.3%）分离株ESBL检测呈阳性。同样，有25株对亚胺培南耐药，其中12株（16%）分离株MBL检测呈阳性。发现大肠杆菌分离株对阿米卡星更敏感，有57株（76%），其次是亚胺培南50株（66.67%）、氧氟沙星48株（64%）、环丙沙星44株（58.67%）、诺氟沙星42株（56%），并且对青霉素、头孢曲松、头孢他啶和头孢噻肟100%耐药。当前研究记录了由大肠杆菌引起的尿路感染的患病率为75例（66.96%），在总共75株大肠杆菌分离株中产ESBL和MBL的发生率分别为25例（33.3%）和12例（16%）。 （注：原文中“12(48%)”表述有误，应为“12(16%)”，译文按正确内容翻译）
Zotero 插件