Wu Jing-Biao, Tang Ya-Ling, Liang Xin-Hua
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan, People's Republic of China,
Onco Targets Ther. 2018 Oct 17;11:6901-6909. doi: 10.2147/OTT.S172042. eCollection 2018.
Vascular normalization is a new concept of targeting angiogenesis to restore vessel structure and function and to increase blood perfusion and delivery of drugs. It has been confirmed that vascular normalization can decrease relapse and benefit other cancer therapy, including chemotherapy, radiotherapy, and immune cell therapy. The key point of this therapy is to inhibit pro-angiogenic factors and make it be balanced with anti-angiogenic factors, resulting in a mature and normal vessel characteristic. Vascular endothelial growth factor (VEGF) is a key player in the process of tumor angiogenesis, and inhibiting VEGF is a primary approach to tumor vessel normalization. Herein, we review newly uncovered mechanisms governing angiogenesis and vascular normalization of cancer and place emphasis on targeting VEGF pathway to normalize the vasculature. Also, important methods to depress VEGF pathway and make tumor vascular are discussed.
血管正常化是一种针对血管生成的新概念，旨在恢复血管结构和功能，增加血液灌注以及药物递送。已经证实，血管正常化可以减少复发，并使包括化疗、放疗和免疫细胞治疗在内的其他癌症治疗受益。这种治疗的关键在于抑制促血管生成因子，并使其与抗血管生成因子保持平衡，从而形成成熟且正常的血管特征。血管内皮生长因子（VEGF）是肿瘤血管生成过程中的关键因素，抑制VEGF是实现肿瘤血管正常化的主要方法。在此，我们综述了新发现的癌症血管生成和血管正常化调控机制，并着重介绍了靶向VEGF通路以使脉管系统正常化的方法。此外，还讨论了抑制VEGF通路和使肿瘤血管正常化的重要方法。
