Yu Wanpeng, Liang Xiao, Li Xiangdong, Zhang Yuan, Sun Zhenqing, Liu Ying, Wang Jianxun
Institute for Translational Medicine, Medical College of Qingdao University, Qingdao 266021, China;
College of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China.
Onco Targets Ther. 2018 Oct 17;11:7109-7123. doi: 10.2147/OTT.S183600. eCollection 2018.
MicroRNAs (miRNAs) are small and highly conserved noncoding RNAs that regulate gene expression at the posttranscriptional level by binding to the 3'-UTR of target mRNAs. Recently, increasing evidence has highlighted their profound roles in various pathological processes, including human cancers. Deregulated miRNAs function as either oncogenes or tumor suppressor genes in multiple cancer types. Among them, miR-195 has been reported to significantly impact oncogenicity in various neoplasms by binding to critical genes and signaling pathways, enhancing or inhibiting the progression of cancers. In this review, we focus on the expression of miR-195 in regulatory mechanisms and tumor biological processes and discuss the future potential therapeutic implications of diverse types of human malignancies.
微小RNA（miRNA）是一类短小且高度保守的非编码RNA，它们通过与靶mRNA的3'-非翻译区（3'-UTR）结合，在转录后水平调控基因表达。近来，越来越多的证据突显了它们在包括人类癌症在内的各种病理过程中的重要作用。失调的miRNA在多种癌症类型中既可以作为癌基因，也可以作为肿瘤抑制基因发挥作用。其中，据报道miR-195通过与关键基因和信号通路结合，增强或抑制癌症进展，从而对各种肿瘤的致癌性产生显著影响。在本综述中，我们聚焦于miR-195在调控机制和肿瘤生物学过程中的表达，并探讨其在各类人类恶性肿瘤未来潜在的治疗意义。
