Wang Dan-Dan, Chen Xiu, Yu Dan-Dan, Yang Su-Jin, Shen Hong-Yu, Sha Huan-Huan, Zhong Shan-Liang, Zhao Jian-Hua, Tang Jin-Hai
The First Clinical School of Nanjing Medical University, Nanjing 210009, China; The Forth Clinical School of Nanjing Medical University, Nanjing 210009, China.
The Forth Clinical School of Nanjing Medical University, Nanjing 210009, China; Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital Cancer Institute of Jiangsu Province, Baiziting 42, Nanjing 210009, China.
Gene. 2016 Oct 15;591(2):313-9. doi: 10.1016/j.gene.2016.06.035. Epub 2016 Jun 17.
microRNAs (miRNAs) are small noncoding RNAs that could regulate post-transcription level through binding to 3' untranslated region (3'UTR) of target messenger RNAs (mRNAs), which were reported to be related with the incidence and development of diverse neoplasms. Among them, miR-197 was confirmed to play a vital role of oncogene or anti-oncogene in different cancers via targeting key tumorigenic or tumor-suppressive genes. Additionally, miR-197 had extensively been studied in carcinogenesis progression of cancers through various mechanisms, including apoptosis, proliferation, angiogenesis, metastasis, drug resistance and tumor suppressor, and also played a role in prognosis of cancers. In this review, we summarized the roles of miR-197 in cancers and considered it as a potentially novel biomarker for different cancers, offering an alternatively secure and effective tool in molecular targeting cancer treatment.
微小RNA（miRNA）是一类小的非编码RNA，其可通过与靶信使核糖核酸（mRNA）的3'非翻译区（3'UTR）结合来调控转录后水平，据报道其与多种肿瘤的发生和发展相关。其中，miR-197已被证实通过靶向关键的致癌或抑癌基因在不同癌症中发挥癌基因或抑癌基因的重要作用。此外，miR-197已通过包括凋亡、增殖、血管生成、转移、耐药性和肿瘤抑制等多种机制在癌症的致癌进程中得到广泛研究，并且在癌症预后中也发挥作用。在本综述中，我们总结了miR-197在癌症中的作用，并认为它是不同癌症潜在的新型生物标志物，为分子靶向癌症治疗提供了一种安全有效的替代工具。
