Bunyatyan N D, Drogovoz S M, Kononenko A V, Prokofiev A B
I.M. Sechenov First Moscow State Medical University, Moscow, Russia; Federal State Budgetary Institution "Scientific Centre for Expert Evaluation of Medicinal Products" of the Ministry of Health of the Russian Federation, Moscow, Russia.
National University of Pharmacy, Kharkiv, Ukraine.
Vopr Kurortol Fizioter Lech Fiz Kult. 2018;95(5):72-76. doi: 10.17116/kurort20189505172.
Carboxytherapy (the treatment based on carbon dioxide injections) is a multipurpose and widely used medical technology. The use of CO injections (intracutaneous, subcutaneous, and pneumopuncture) have substantially supplemented and increased the practical relevance of carboxytherapy as a method for the treatment of many diseases. Thanks to it physiological properties, CO has antihypoxic, antioxidant, vasodilatory, anti-inflammatory, analgesic, and spasmolytic activities; moreover, it improves blood viscosity, stimulates neoangiogenesis, and regenerative processes. Carbon dioxide is a sort of biochemical 'peacemaker' in tissue oxygenation: when blood cells are exposed to high CO concentrations (Bohr effect), the rate of gas exchange (CO and O) increases. The human organism interprets carboxytherapy (local hypercapnia) as oxygen deficiency and responses to it by boosting not only the blood flow, but also the vascular endothelial growth factor which stimulates neoangiogenesis and in the long run improves blood supply and tissue trophism. The multiple mechanisms of action, polymodal efficacy, a tool kit with a wide range of detectors and various modes of treatment make carboxytherapy a popular medical technology all over the world, namely in cosmetology, dermatology, aesthetic medicine, angiology, orthopaedics, cardiology, neurology, pulmonology, gynaecology, urology, proctology, plastic and general surgery, and other areas. Carboxytherapy provides a perfect example of the off-label usage in medicine that made it one of the most extensively applied medical technology for the treatment of various diseases despite the lack of the preclinical data and scarce relevant information available in textbooks, reference books and booklets.
羧基疗法（基于注射二氧化碳的治疗方法）是一种用途广泛且被广泛应用的医学技术。注射二氧化碳（皮内、皮下和气针注射）极大地补充并提高了羧基疗法作为一种治疗多种疾病方法的实际应用价值。由于其生理特性，二氧化碳具有抗缺氧、抗氧化、血管舒张、抗炎、镇痛和解痉作用；此外，它还能改善血液黏稠度，刺激新血管生成和再生过程。二氧化碳在组织氧合过程中起着某种生化“调解者”的作用：当血细胞暴露于高浓度二氧化碳时（波尔效应），气体交换（二氧化碳和氧气）速率会增加。人体将羧基疗法（局部高碳酸血症）视为缺氧状态，并通过不仅增加血流量，还增加刺激新血管生成的血管内皮生长因子来做出反应，从长远来看改善血液供应和组织营养状况。其多种作用机制、多模式疗效、配备多种检测仪器和各种治疗模式的工具包，使羧基疗法在全球成为一种受欢迎的医学技术，尤其是在美容学、皮肤病学、美容医学、血管学、骨科、心脏病学、神经病学、肺病学、妇科、泌尿科、直肠科、整形和普通外科以及其他领域。羧基疗法是医学中药物标签外使用的一个完美例子，尽管缺乏临床前数据，且教科书、参考书和手册中相关信息稀少，但它却成为治疗各种疾病应用最广泛的医学技术之一。
