川崎病临床病程的季节性。
Seasonality in clinical courses of Kawasaki disease.
机构信息
Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.
Department of Pediatrics, National Hospital Organization Kokura Medical Center, Kitakyushu, Japan.
出版信息
Arch Dis Child. 2019 Jul;104(7):694-696. doi: 10.1136/archdischild-2018-315267. Epub 2018 Nov 9.
OBJECTIVE
Epidemics of Kawasaki disease (KD) are well known; however, the seasonal variation in the clinical course of KD is uncertain. The aim of this study was to investigate the seasonality in the clinical course of KD.
METHODS
This study included 744 patients who were admitted to six hospitals in Kitakyushu City for KD from 2010 to 2014. We divided the patients into two groups according to the average monthly temperature (warm and cold periods) and compared the clinical courses of KD.
RESULTS
The clinical courses of 715 patients who were initially treated with intravenous immunoglobulin (IVIG) were investigated. The proportion of patients with resistance to the initial IVIG therapy was significantly higher during the warm period than during the cold period (p=0.016). There was no seasonality in the proportion of patients with coronary artery abnormalities.
CONCLUSION
Seasonality was observed in the response to IVIG therapy of patients with KD.
目的
川崎病（KD）的流行情况众所周知，但其临床病程的季节性变化尚不确定。本研究旨在探讨 KD 临床病程的季节性。
方法
本研究纳入了 2010 年至 2014 年期间在北九州市 6 家医院因 KD 入院的 744 例患者。我们根据平均月温度（温暖期和寒冷期）将患者分为两组，并比较了 KD 的临床病程。
结果
对 715 例最初接受静脉注射免疫球蛋白（IVIG）治疗的患者进行了临床病程调查。在温暖期，对初始 IVIG 治疗有抵抗的患者比例明显高于寒冷期（p=0.016）。患有冠状动脉异常的患者比例无季节性变化。
结论
KD 患者对 IVIG 治疗的反应存在季节性。
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