Rigante Donato
Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Università Cattolica Sacro Cuore, Rome, Italy.
Mediterr J Hematol Infect Dis. 2020 Jul 1;12(1):e2020039. doi: 10.4084/MJHID.2020.039. eCollection 2020.
Although the etiology of Kawasaki disease (KD) remains elusive, the available evidence indicates that the primum movens may be a dysregulated immune response to various microbial agents, leading to cytokine cascade and endothelial cell activation in patients with KD. Documented infections by different viruses in many individual cases have been largely reported and are discussed herein, but attempts to demonstrate their causative role in the distinctive KD scenario and KD epidemiological features have been disappointing. To date, no definite link has been irrefutably found between a single infection and KD.
尽管川崎病（KD）的病因仍不明确，但现有证据表明，首要因素可能是对各种微生物制剂的免疫反应失调，导致KD患者体内细胞因子级联反应和内皮细胞活化。许多个别病例中已大量报道了不同病毒的感染情况，并在此进行讨论，但试图证明它们在独特的KD病情及KD流行病学特征中的致病作用，结果却令人失望。迄今为止，尚未确凿地发现单一感染与KD之间存在明确联系。
