Simgen A
Klinik für Diagnostische und Interventionelle Neuroradiologie, Universitätsklinikum des Saarlandes, Kirrberger Str. 1, 66424, Homburg/Saar, Deutschland.
Radiologe. 2018 Dec;58(12):1060-1066. doi: 10.1007/s00117-018-0458-5.
Nowadays chemotherapy and radiotherapy are fundamental therapy concepts in the guidelines of malignant tumors of the central nervous system. Both therapy concepts can cause neurological symptoms or white matter alterations can occur, which can be classified into acute, subacute and chronic. Both symptoms and white matter alterations during acute and subacute phases are in most cases completely reversible, whereas chronic white matter alterations can lead to severe neurological limitations and further impair the quality of life of cancer patients.
如今，化疗和放疗是中枢神经系统恶性肿瘤诊疗指南中的基本治疗理念。这两种治疗理念都可能引发神经症状或出现白质改变，这些改变可分为急性、亚急性和慢性。在大多数情况下，急性和亚急性期的症状及白质改变都是完全可逆的，而慢性白质改变可能导致严重的神经功能受限，并进一步损害癌症患者的生活质量。
