Peterslund N A, Larsen M L, Mygind H
Department of Medicine, Marselisborg Hospital, Aarhus, Denmark.
Scand J Infect Dis. 1988;20(2):225-8. doi: 10.3109/00365548809032442.
Acyclovir crystals in the urine of a 28-year-old woman are described. The patient received intravenous acyclovir for herpes encephalitis. The crystalluria was accompanied by impairment of the renal tubules as evidenced by increased urinary beta-2-microglobulin excretion. Consecutive series of 60 patients on oral acyclovir and 20 patients on intravenous acyclovir were studied in order to define the frequency of acyclovir crystalluria. None of the patients studied had crystalluria, and none elevated serum creatinine levels. It is suggested that acyclovir crystalluria might be an early sign of acyclovir crystal nephropathy.
本文描述了一名28岁女性尿液中的阿昔洛韦晶体。该患者因疱疹性脑炎接受静脉注射阿昔洛韦治疗。结晶尿伴有肾小管损害，尿β2-微球蛋白排泄增加证明了这一点。为了确定阿昔洛韦结晶尿的发生率，对连续60例口服阿昔洛韦的患者和20例静脉注射阿昔洛韦的患者进行了研究。所有研究患者均无结晶尿，且血清肌酐水平均未升高。提示阿昔洛韦结晶尿可能是阿昔洛韦结晶肾病的早期表现。
