Roach M R, Song S H
Department of Biophysics, University of Western Ontario, London, Canada.
Scanning Microsc. 1988 Jun;2(2):994-1004.
All large arteries contain elastin, collagen, and muscle which can be seen with light microscopy and transmission electron microscopy. Elastin forms an internal elastic lamina (IEL) in all arteries, but also forms multiple fenestrated sheets in the media of the aorta and other large arteries. The fenestrations in the media are larger than those in the IEL. The adventitial elastin is more fibrous and often contains tubular elastin surrounding vasa vasorum when prepared by removing all non-elastin by placing the aorta in 0.1 N NaOH at 70-75 degrees C for five hours. The fenestrations are larger near branches and in an experimentally created poststenotic dilatation. Atherosclerosis appears associated with both new elastin formation in early atherosclerosis and elastolysis in late disease.
所有大动脉都含有弹性蛋白、胶原蛋白和肌肉组织，通过光学显微镜和透射电子显微镜均可观察到。弹性蛋白在所有动脉中形成内弹性膜（IEL），但在主动脉和其他大动脉的中膜也形成多个有窗孔的薄片。中膜的窗孔比内弹性膜中的窗孔大。当通过将主动脉置于70 - 75摄氏度的0.1 N氢氧化钠中5小时去除所有非弹性蛋白来制备时，外膜弹性蛋白更呈纤维状，并且通常包含围绕血管滋养管的管状弹性蛋白。在分支附近以及实验性造成的狭窄后扩张处，窗孔更大。动脉粥样硬化似乎与早期动脉粥样硬化中弹性蛋白的新生成以及疾病后期的弹性蛋白溶解均有关联。
