Department of Nutrition Physiology and Animal Product Quality, Institute of Animal Science, CZ-104 00 Praha-Uhříněves, Czech Republic.
Department of Nutrition Physiology and Animal Product Quality, Institute of Animal Science, CZ-104 00 Praha-Uhříněves, Czech Republic.
Int J Biol Macromol. 2019 Feb 1;122:499-502. doi: 10.1016/j.ijbiomac.2018.10.180. Epub 2018 Oct 26.
The effect of octadecylamide of alginic acid on serum and hepatic cholesterol, and the faecal output of fat and sterols was examined in female rats fed diets containing cholesterol and palm fat at 10 and 50 g kg, respectively. Cholesterol supplementation significantly increased serum and hepatic cholesterol concentrations, and faecal output of cholesterol and coprostanol. Cholesterol and amidated alginate supplementations changed the profile of fatty acids in the faeces. Cholesterol increased molar percentages of saturated fatty acids and amidated alginate reversed this effect. Amidated alginate, supplied at 10, 20 and 40 g kg, significantly decreased serum cholesterol from 2.82 to 2.00, 1.95, and 1.63 μmol mL, respectively, and significantly decreased hepatic cholesterol from 13.8 to 9.33, 7.81 and 6.3 μmol g, respectively. Amidated alginate increased the faecal output of fat and neutral sterols in a dose-dependent manner. In contrast, the output of bile acids was significantly decreased. The faecal outputs of fat and serum cholesterol were negatively correlated. At the highest concentration tested, amidated alginate significantly reduced the serum concentration of triacylglycerols. It can be concluded that amidated alginate is an effective cholesterol-lowering agent and sorbent of dietary fat.
十八烷酰胺藻酸钠对喂饲含胆固醇（10g/kg 饲料）和棕榈油（50g/kg 饲料）的雌性大鼠血清和肝胆固醇及粪脂和固醇排出量的影响。胆固醇补充使血清和肝胆固醇浓度及胆甾醇和粪甾烷醇排出量显著增加。胆固醇和酰胺化藻酸钠补充改变了粪便中脂肪酸的组成。胆固醇增加了饱和脂肪酸的摩尔百分率，而酰胺化藻酸钠则使这种作用逆转。酰胺化藻酸钠以 10、20 和 40g/kg 的剂量添加时，可使血清胆固醇分别从 2.82mmol/ml 降至 2.00、1.95 和 1.63mmol/ml，使肝胆固醇分别从 13.8μmol/g 降至 9.33、7.81 和 6.3μmol/g，均有显著降低作用。酰胺化藻酸钠可使粪脂和中性固醇的排出量呈剂量依赖性增加，而胆汁酸的排出量则显著减少。粪脂和血清胆固醇的排出量呈负相关。在试验的最高浓度时，酰胺化藻酸钠可使血清三酰甘油浓度显著降低。由此可见，酰胺化藻酸钠是一种有效的降胆固醇剂和膳食脂肪的吸附剂。
