Mansour Hicham, Feghali Mireille, Saleh Nadine, Zeitouny Mona
Department of Restorative and Esthetic, Faculty of Dentistry, Lebanese University. Beirut (Lebanon).
Division of epidemiology and biostatistics - Faculty of Public Health - Lebanese University, Beirut (Lebanon).
Pharm Pract (Granada). 2018 Jul-Sep;16(3):1272. doi: 10.18549/PharmPract.2018.03.1272. Epub 2018 Sep 29.
Explore antibiotic use, assess conformity with evidence-practice guidelines, and describe knowledge and attitudinal factors among Lebanese dentists.
National cross-sectional telephonic survey, using a standardized questionnaire addressing demographic, educational and professional data, usual antibiotics prophylactic and curative prescription pattern and influential factors, knowledge concerning antibiotics use in selected patient-populations, and attitude regarding antimicrobial resistance. Analyses used descriptive statistics, and bivariate analysis to observe predictors of higher knowledge.
the overall response rate for the study was around 21%. 322 dentists participated. On average, 17.51% of consultations resulted in antibiotic use; previous antibiotic experience mostly influenced prescriptions (81.3%). Referral of pregnant and lactating women and cardiac patients, when antibiotics are needed, was high (26.9%, 28.5% and 79.4%, respectively). Macrolides were the dominant first-line antibiotics in penicillin allergy (47.4%). Penicillins were most common for pregnant and lactating women. Penicillins (95.0%), 2g (63.9%), and 1 hour pre-procedure (34%) were the main components of prophylaxis for cardiac patients. Prophylactic and curative use varied widely; few dentists exhibited guideline-conform prescriptions. Mean knowledge scores of prophylaxis for cardiac and non-cardiac patients, and antibiotics' side effects were predominantly poor (46.75±14.82, 39.21±33.09 and 20.27±18.77, respectively over 100). Practicing outside Beirut, undergraduate qualification in Lebanon, and post-graduate qualification predicted higher knowledge. 75.9% acknowledged the contribution of dentistry-based prescribing to antibiotic resistance and 94.7% knew at least one cause of resistance.
Dentists show positive attitude towards antimicrobial resistance. Yet, they lack uniformity in antibiotic stewardship. Poor knowledge and guideline-incongruent prophylactic and therapeutic prescribing are observed. Development of targeted interventions is needed to promote judicious antibiotic use within Lebanese dentistry.
探讨抗生素使用情况,评估与循证实践指南的符合程度,并描述黎巴嫩牙医的知识和态度因素。
采用全国性横断面电话调查,使用标准化问卷,内容涉及人口统计学、教育和专业数据、常用抗生素的预防性和治疗性处方模式及影响因素、特定患者群体中抗生素使用的知识以及对抗菌药物耐药性的态度。分析采用描述性统计和双变量分析,以观察知识水平较高的预测因素。
该研究的总体应答率约为21%。322名牙医参与。平均而言,17.51%的会诊导致使用抗生素;以往的抗生素使用经验对处方影响最大(81.3%)。在需要使用抗生素时,转诊孕妇、哺乳期妇女和心脏病患者的比例较高(分别为26.9%、28.5%和79.4%)。大环内酯类是青霉素过敏时的主要一线抗生素(47.4%)。青霉素是孕妇和哺乳期妇女最常用的药物。青霉素(95.0%)、2克(63.9%)和术前1小时(34%)是心脏病患者预防用药的主要组成部分。预防性和治疗性使用差异很大;很少有牙医开具符合指南的处方。对心脏病和非心脏病患者预防用药以及抗生素副作用的平均知识得分普遍较低(满分100分,分别为46.75±14.82、39.21±33.09和20.27±18.77)。在贝鲁特以外地区执业、黎巴嫩本科学历和研究生学历是知识水平较高的预测因素。75.9%的人承认牙科处方对抗生素耐药性有影响,94.7%的人至少知道一种耐药原因。
牙医对抗菌药物耐药性持积极态度。然而,他们在抗生素管理方面缺乏一致性。观察到知识水平较低以及预防和治疗性处方不符合指南的情况。需要制定有针对性的干预措施,以促进黎巴嫩牙科领域合理使用抗生素。