Joseph-Mathurin Nelly, Su Yi, Blazey Tyler M, Jasielec Mateusz, Vlassenko Andrei, Friedrichsen Karl, Gordon Brian A, Hornbeck Russ C, Cash Lisa, Ances Beau M, Veale Thomas, Cash David M, Brickman Adam M, Buckles Virginia, Cairns Nigel J, Cruchaga Carlos, Goate Alison, Jack Clifford R, Karch Celeste, Klunk William, Koeppe Robert A, Marcus Daniel S, Mayeux Richard, McDade Eric, Noble James M, Ringman John, Saykin Andrew J, Thompson Paul M, Xiong Chengjie, Morris John C, Bateman Randall J, Benzinger Tammie L S
Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, USA.
Banner Alzheimer's Institute, Phoenix, AZ, USA.
Alzheimers Dement (Amst). 2018 Sep 27;10:669-677. doi: 10.1016/j.dadm.2018.08.012. eCollection 2018.
F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is commonly used to estimate neuronal injury in Alzheimer's disease (AD). Here, we evaluate the utility of dynamic PET measures of perfusion using C-Pittsburgh compound B (PiB) to estimate neuronal injury in comparison to FDG PET.
FDG, early frames of PiB images, and relative PiB delivery rate constants (PiB-R1) were obtained from 110 participants from the Dominantly Inherited Alzheimer Network. Voxelwise, regional cross-sectional, and longitudinal analyses were done to evaluate the correlation between images and estimate the relationship of the imaging biomarkers with estimated time to disease progression based on family history.
Metabolism and perfusion images were spatially correlated. Regional PiB-R1 values and FDG, but not early frames of PiB images, significantly decreased in the mutation carriers with estimated year to onset and with increasing dementia severity.
Hypometabolism estimated by PiB-R1 may provide a measure of brain perfusion without increasing radiation exposure.
氟代脱氧葡萄糖（FDG）正电子发射断层扫描（PET）常用于评估阿尔茨海默病（AD）中的神经元损伤。在此，我们评估使用碳-匹兹堡化合物B（PiB）进行灌注动态PET测量以估计神经元损伤的效用，并与FDG PET进行比较。
从显性遗传阿尔茨海默病网络的110名参与者中获取FDG、PiB图像的早期帧以及相对PiB递送速率常数（PiB-R1）。进行体素级、区域横断面和纵向分析，以评估图像之间的相关性，并根据家族史估计成像生物标志物与疾病进展估计时间之间的关系。
代谢和灌注图像在空间上相关。在估计发病年份的突变携带者以及痴呆严重程度增加的情况下，区域PiB-R1值和FDG显著降低，但PiB图像的早期帧未出现这种情况。
PiB-R1估计的代谢减低可能提供一种在不增加辐射暴露的情况下测量脑灌注的方法。
