[Mechanism of renal allograft rejection].

Renal allograft rejection, in an immunocompetent subject, résults from a cellular and humoral interaction. Lymphokines, which are immunity mediators (particularly interleukin 1 and 2, and gamma interferon) modulate these different cellular populations, among which T lymphocytes play a major role. The current knowledge of rejection mechanisms allows us to evaluate the principal targets of immunosuppressive drugs used to treat allograft rejection.