Department of Physics, Jadavpur University, Kolkata 700032, India.
Department of Chemistry, Jadavpur University, Kolkata 700032, India.
Diabetes Res Clin Pract. 2018 Dec;146:278-288. doi: 10.1016/j.diabres.2018.10.025. Epub 2018 Nov 10.
Diabetes mellitus occurs due to either deficiency of insulin or resistance to insulin. Synthetic drugs and insulin therapy against diabetes possess numerous drawbacks. Diabetic people are advised to choose low-glycemic food and herbal products to control diabetes. This study aims to examine the synergistic effects of aqueous root Salep ofGymnadenia orchidis Lindl and pumpkin seed powder on Streptozotocin induced diabetic mice.
Out of 6 groups, animals in 2 groups were kept as control and rest 4 groups were made diabetic by Streptozotocin. Animals in one diabetic group were supplemented with effective dose (200 mg/kg of body weight) of root Salep, one with pumpkin seed powder (5%) mixed food, and another with Salep and pumpkin seed food. Changes in various biochemical parameters, DNA damage and liver and kidney structures were noted after 21 days treatment.
Salep with pumpkin seed supplementation significantly normalized the alterations of different biochemical parameters of diabetic mice. The DNA damage in blood cells of diabetic mice was recovered by this supplementation. Terpenoids of root Salep and anti-oxidants of pumpkin seed may play the active role against diabetes.
The root Salep and pumpkin seed synergistically prevent diabetic complications and could be better supplementation against type-2 diabetes.
糖尿病的发生是由于胰岛素缺乏或胰岛素抵抗。针对糖尿病的合成药物和胰岛素治疗存在诸多弊端。糖尿病患者被建议选择低血糖食物和草药产品来控制糖尿病。本研究旨在研究兰花根茎水提物和南瓜籽粉对链脲佐菌素诱导的糖尿病小鼠的协同作用。
在 6 组动物中，2 组作为对照，其余 4 组通过链脲佐菌素诱导糖尿病。一组糖尿病动物给予有效剂量（200mg/kg 体重）的根茎 Salep，一组给予 5%南瓜籽粉混合食物，另一组给予 Salep 和南瓜籽粉食物。治疗 21 天后，观察各种生化参数、DNA 损伤以及肝肾功能结构的变化。
Salep 与南瓜籽粉补充显著使糖尿病小鼠的不同生化参数恢复正常。这种补充还恢复了糖尿病小鼠血细胞的 DNA 损伤。根 Salep 的萜类化合物和南瓜籽的抗氧化剂可能在防治糖尿病方面发挥了积极作用。
根 Salep 和南瓜籽协同预防糖尿病并发症，可能是 2 型糖尿病更好的补充剂。
