Richard J L, Rodier M, Monnier L, Orsetti A, Mirouze J
Service de Diabétologie, Centre Médico-Chirurgical, Grau du Roi, France.
Diabete Metab. 1988 Mar-Apr;14(2):114-8.
The aim of the present study was to evaluate the acute effect of acarbose, an alpha-glycosidase inhibitor, on glycemic and insulin response to an oral sucrose load in sixteen patients suffering from idiopathic reactive hypoglycemia. In each subject, two oral sucrose tolerance tests (45 g/m2 body surface) were performed with either placebo or acarbose in a double-blind random order. Compared with placebo, acarbose dramatically flattened the blood glucose curve with values significantly lower from 30 to 90 min and higher from 150 to 240 min. Moreover the magnitude of both glucose peak and nadir, and rate of blood glucose rise and fall were significantly reduced by acarbose as was the hypoglycemic index. Plasma insulin levels from 30 to 120 min, insulin peak and area under the insulin curve were significantly lower after ingestion of acarbose. Thus, in reducing the early rise in blood glucose and insulin after sucrose ingestion, acarbose prevents the occurrence of reactive hypoglycemia; the present study confirms that this drug may be of value in the treatment of reactive hypoglycemia.
本研究的目的是评估α-糖苷酶抑制剂阿卡波糖对16例特发性反应性低血糖患者口服蔗糖负荷后血糖和胰岛素反应的急性影响。对每名受试者进行两次口服蔗糖耐量试验（45g/m²体表面积），试验中以双盲随机顺序分别给予安慰剂或阿卡波糖。与安慰剂相比，阿卡波糖显著使血糖曲线变平缓，在30至90分钟时血糖值显著降低，在150至240分钟时血糖值显著升高。此外，阿卡波糖还显著降低了血糖峰值和谷值的幅度、血糖升降速率以及低血糖指数。服用阿卡波糖后，30至120分钟的血浆胰岛素水平、胰岛素峰值和胰岛素曲线下面积均显著降低。因此，阿卡波糖通过降低蔗糖摄入后血糖和胰岛素的早期升高，预防反应性低血糖的发生；本研究证实该药物在治疗反应性低血糖方面可能具有价值。
