Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
J Microbiol Immunol Infect. 2020 Aug;53(4):640-646. doi: 10.1016/j.jmii.2018.10.004. Epub 2018 Oct 31.
BACKGROUND/PURPOSE: Differences exist among racial and ethnic groups in the prevalence and severity of allergic diseases. However, influence of population admixing on allergic disease has not been studied. We examined the effect of population admixing on the occurrence of allergic disease.
We reviewed the data of 68,043 adolescents who participated in the 11th Korea Youth Risk Behavior Web-based Survey, which provides a sample that is representative of the entire Korean middle school and high school student population. Multi-ethnic status was determined by using parental country of birth and prevalence of asthma, allergic rhinitis (AR), and atopic dermatitis (AD) was determined by questionnaire.
Multi-ethnic adolescents accounted for approximately 0.9% of the total adolescents. Prevalence of asthma was significantly higher in multi-ethnic group than non multi-ethnic group while that of AR and AD was significantly higher in non multi-ethnic group than multi-ethnic group. Parental region of country at birth showed a significant difference in prevalence of allergic disease. Univariate analysis found that urbanity, perceived economic status (PES), parental region of country at birth, and environmental tobacco smoke (ETS) showed a significant odds ratio (OR) in asthma, AR, and AD. Body mass index (BMI) showed a significant OR in asthma and AD. After adjusting for urbanity, PES, BMI and ETS, multiethnicity showed significantly lower OR in AR and AD.
Population admixing appears to have significant effect on the prevalence of allergic disease. Further study will be needed to clarify the effect of population admixing on prevalence of allergic disease.
背景/目的：不同种族和族裔群体之间过敏疾病的流行率和严重程度存在差异。然而，人群混合对过敏疾病的影响尚未得到研究。我们研究了人群混合对过敏疾病发生的影响。
我们回顾了 68043 名青少年参加的第 11 届韩国青少年风险行为网络调查的数据，该调查提供了一个代表整个韩国中学生和高中生群体的样本。多民族身份通过父母的出生国确定，哮喘、过敏性鼻炎（AR）和特应性皮炎（AD）的患病率通过问卷调查确定。
多民族青少年约占总青少年的 0.9%。多民族组的哮喘患病率明显高于非多民族组，而非多民族组的 AR 和 AD 患病率明显高于多民族组。父母出生国家的地区在过敏疾病的患病率上存在显著差异。单因素分析发现，城市化程度、经济状况感知（PES）、父母出生国家的地区以及环境烟草烟雾（ETS）在哮喘、AR 和 AD 中显示出显著的比值比（OR）。体重指数（BMI）在哮喘和 AD 中显示出显著的 OR。在调整城市化程度、PES、BMI 和 ETS 后，多民族在 AR 和 AD 中的 OR 显著降低。
人群混合似乎对过敏疾病的流行率有显著影响。需要进一步研究以阐明人群混合对过敏疾病流行率的影响。
