Department of Paediatric Nephrology, Southampton Children's Hospital, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre-Nutrition, University Hospital Southampton NHS Foundation Trust, Southampton General Hospital, E level, Southampton, UK.
Faculty of Medicine, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre-Nutrition, University Hospital Southampton NHS Foundation Trust, Southampton General Hospital, E level, Southampton, UK.
J Ren Nutr. 2019 May;29(3):205-208. doi: 10.1053/j.jrn.2018.09.003. Epub 2018 Nov 10.
Our aim was to assess the vitamin B6 intake and biochemical status in a sample of children who have undergone renal transplantation.
A prospective observational study was performed in 10 pediatric renal transplant recipients to determine their vitamin B6 status through dietary assessment and serum Pyridoxal 5'-phosphate (PLP) measurement.
Ten children (mean age of 11.9 years) had median serum PLP concentrations of 62.45 nmol/L (interquartile range ±83.40). Two children (20%) had values above the reference range, and none below. Mean vitamin B6 intake was 138.7% of reference nutrient intake (standard deviation ±35.2%). No children were in receipt of vitamin B6 supplementation.
There is no previous literature on vitamin B6 status in children who have undergone renal transplantation. In adult transplant recipients, elevated serum PLP concentrations have been described and ascribed to possible excessive intakes. In this sample, no children appeared biochemically deficient, but 20% had elevated concentrations. Dietary intakes were not excessive, and no children reported oral Vitamin B6 supplementation. Exploration of vitamin B6 metabolism in this population is required.
评估肾移植儿童的维生素 B6 摄入量和生化状况。
对 10 名接受肾移植的儿科患者进行前瞻性观察研究，通过饮食评估和血清吡哆醛 5'-磷酸（PLP）测量来确定其维生素 B6 状况。
10 名儿童（平均年龄 11.9 岁）的血清 PLP 中位数浓度为 62.45nmol/L（四分位距±83.40）。有 2 名儿童（20%）的数值高于参考范围，没有低于参考范围的。平均维生素 B6 摄入量为参考营养素摄入量的 138.7%（标准差±35.2%）。没有儿童接受维生素 B6 补充。
目前尚无关于肾移植儿童维生素 B6 状况的文献。在成年移植受者中，已描述并归因于可能过量摄入的血清 PLP 浓度升高。在本样本中，没有儿童出现生化缺乏，但有 20%的儿童浓度升高。膳食摄入量不过量，也没有儿童报告口服维生素 B6 补充。需要探索该人群的维生素 B6 代谢。
