Passias Peter G, Bortz Cole A, Pierce Katherine E, Segreto Frank A, Horn Samantha R, Vasquez-Montes Dennis, Lafage Virginie, Brown Avery E, Ihejirika Yael, Alas Haddy, Varlotta Christopher, Ge David H, Shepard Nicholas, Oh Cheongeun, DelSole Edward M, Jankowski Pawel P, Hockley Aaron, Diebo Bassel G, Vira Shaleen N, Sciubba Daniel M, Raad Michael, Neuman Brian J, Gerling Michael C
Department of Orthopaedic Surgery, NYU School of Medicine/NYU Langone Orthopedic Hospital at NYU Langone Medical Center, New York, NY, USA.
Department of Orthopaedic Surgery, NYU School of Medicine/NYU Langone Orthopedic Hospital at NYU Langone Medical Center, New York, NY, USA.
J Clin Neurosci. 2019 Mar;61:147-152. doi: 10.1016/j.jocn.2018.10.104. Epub 2018 Nov 10.
The Clavien-Dindo grading allows for broad comparison of perioperative surgical complications, and a temporal analysis of complications following ASD-corrective surgery. NSQIP database was utilized from 2010 to 2014 to isolate patients. Complications were stratified by Clavien complication (Cc) grade, and patients grouped by highest Cc grade: I, II, III, IV, V. Secondary analysis grouped by minor (I, II, III) and severe (IV, V). Comorbidity burden was assessed with a NSQIP-modified Charlson Comorbidity Index (CCI) and frailty was measured with a 5-factor modified frailty index (mFI). From 2010 to 2014, 2971 patients (57 yrs, 58% F) underwent surgery for ASD (3.4 ± 4.1 levels; surgical approach: 46% anterior, 44% posterior, 10% combined), the rate of which increased 0.01% to 0.13. 32% suffered >1 complication. Patient breakdown by Cc grade: 0% I, 25% II, 3% III, 4% IV, 1% V. Severe Cc patients were more comorbid than minor Cc (CCI 2.8 vs 1.8), had longer operative times (394 min vs 251), and higher rates of osteotomy (29% vs 13%) and iliac fixation (16% vs 5%). Overall CCI (2.1-1.7) and perioperative complication rates (55-29%) decreased, despite increasing surgical invasiveness (2.8-4.5) and increasing frailty score (0.14 ± 0.15 vs 0.16 ± 0.16). Rates of Clavien grade II (39.80-22.20%) and IV (9.40-3.50%) complications also decreased, indicative of surgical improvements and effective preoperative patient selection. The decrease in CCI and increase in the modified frailty score may show that we are becoming more cognizant of discerning of comorbidities, but likely to not to have taken into account frailty, which may have an impact on future health socioeconomics.
Clavien-Dindo分级有助于对围手术期手术并发症进行广泛比较,并对房间隔缺损矫正手术后的并发症进行时间分析。我们利用2010年至2014年的国家外科质量改进计划(NSQIP)数据库筛选患者。并发症按Clavien并发症(Cc)分级进行分层,患者按最高Cc分级分组:I级、II级、III级、IV级、V级。二级分析按轻度(I级、II级、III级)和重度(IV级、V级)进行分组。采用NSQIP改良的Charlson合并症指数(CCI)评估合并症负担,并用5因素改良虚弱指数(mFI)测量虚弱程度。2010年至2014年,2971例患者(年龄57岁,58%为女性)接受了房间隔缺损手术(3.4±4.1个节段;手术入路:46%为前路,44%为后路,10%为联合入路),手术比例从0.01%增至0.13%。32%的患者发生了1种以上并发症。按Cc分级的患者分布情况:I级为0%,II级为25%,III级为3%,IV级为4%,V级为1%。重度Cc患者的合并症比轻度Cc患者更多(CCI分别为2.8和1.8),手术时间更长(分别为394分钟和251分钟),截骨率(分别为29%和13%)和髂骨固定率(分别为16%和5%)更高。尽管手术侵袭性增加(从2.8增至4.5)和虚弱评分增加(分别为0.14±0.15和0.16±0.16),总体CCI(从2.1降至1.7)和围手术期并发症发生率(从55%降至29%)仍有所下降。Clavien II级(从39.80%降至22.20%)和IV级(从9.40%降至3.50%)并发症的发生率也有所下降,这表明手术有改进,术前患者选择有效。CCI的降低和改良虚弱评分的增加可能表明我们对合并症的识别更加了解,但可能没有考虑到虚弱,而虚弱可能会对未来的健康社会经济学产生影响。