Nakhla Sammy G
Department of Medicine, Southern Arizona VA Health Care System, Tucson, AZ 85723, USA.
Case Rep Infect Dis. 2018 Oct 8;2018:8954016. doi: 10.1155/2018/8954016. eCollection 2018.
Coccidioidomycosis, also known as San Joaquin Valley Fever or Valley Fever, is mostly a pulmonary infection caused by inhalation of spores in an endemic region. Dissemination to bone, joints, meninges, and skin occurs less than one percent of the time. Skeletal involvement accounts for approximately half of the disseminated coccidioidomycosis with the vertebrae as the most common skeletal region. We present a very rare case of disseminated coccidioidomycosis with osteomyelitis and compression fracture of the lumbar vertebral body. This case depicts some of the potential issues that can arise in managing coccidioidomycosis, especially when noncompliance to initial azoles occurs, that can lead to dissemination and complicated bone infections necessitating surgical intervention along with continuous medical therapy.
球孢子菌病,也称为圣华金河谷热或河谷热,主要是在流行地区因吸入孢子而引起的肺部感染。传播至骨骼、关节、脑膜和皮肤的情况不到1%。骨骼受累约占播散性球孢子菌病的一半,其中脊椎是最常见的骨骼部位。我们报告一例非常罕见的播散性球孢子菌病合并骨髓炎和腰椎椎体压缩性骨折的病例。该病例描述了在管理球孢子菌病时可能出现的一些潜在问题,尤其是当患者不遵守初始唑类药物治疗时,可能导致疾病播散和复杂的骨感染,需要手术干预以及持续的药物治疗。