Honore Patrick M, De Bels David, Preseau Thierry, Redant Sebastien, Spapen Herbert D
ICU Department, Centre Hospitalier Universitaire Brugmann, Brussels, Belgium.
Emergency Dept, Centre Hospitalier Universitaire Brugmann, Brussels, Belgium.
J Transl Int Med. 2018 Oct 9;6(3):115-127. doi: 10.2478/jtim-2018-0026. eCollection 2018 Sep.
In most of the case, regional citrate anticoagulation is using diluted citrate around 1% depending on the types used in clinical practice. Diluted citrate is much more safer when compared to highly concentrated citrate around 4% or even more. In clinical practice, trisodium citrate is used in high concentration (around 30%) as a bactericidal agent with anticoagulant properties for locking deep venous catheters used in hemodialysis (HD; close to 25-30% of citrate). In this review article, buffer and anticoagulant potential of citrate are discussed during renal replacement therapy in critically ill patients with particular focus on the practical approach at the bedside.
在大多数情况下，根据临床实践中使用的类型，局部枸橼酸抗凝使用的是浓度约为1%的稀释枸橼酸盐。与浓度约为4%甚至更高的高浓度枸橼酸盐相比，稀释枸橼酸盐要安全得多。在临床实践中，枸橼酸钠以高浓度（约30%）用作具有抗凝特性的杀菌剂，用于锁定血液透析（HD）中使用的深静脉导管（接近25%-30%的枸橼酸盐）。在这篇综述文章中，讨论了枸橼酸盐在危重症患者肾脏替代治疗期间的缓冲和抗凝潜力，特别关注床边的实际应用方法。
