Goujard J, Entat M, Maillard F, Mugnier E, Rappaport R, Job J C
INSERM, Unité de Recherches Epidémiologiques sur la mère et l'enfant, Paris, France.
Int J Epidemiol. 1988 Jun;17(2):423-7. doi: 10.1093/ije/17.2.423.
An epidemiological inquiry has been done in France after the notification in the USA and England of four cases of Creutzfeldt-Jakob disease in patients previously treated with hGH. Between 1959, when hGH treatment in France was started, and August 1985, the date the survey began, 1698 patients were registered for treatment. Current information (less than three months old) was obtained for 1620 patients (95.4%). Death was reported in 31 patients, but none could be related to Creutzfeldt-Jakob or similar disease. Pathological events were observed in 213 living patients (13.1%). Among them, four were diseases classified as possibly related to a viral infection. The first case had acute lymphoid leukaemia; the second case had polyradiculoneuritis associated with hepatitis. In both cases the disease resolved completely. Two other patients had acute encephalitis which started less than two years after the onset of treatment and which resolved spontaneously. Even though the acute evolution and the spontaneous clinical recovery are not consistent with Creutzfeldt-Jakob disease, a relationship with hGH therapy could not be completely excluded. Finally, five treated children had later malignancies which raises the question of the long-term secondary effects of hGH upon cellular proliferation.
在美国和英国通报了4例曾接受人生长激素（hGH）治疗的患者患克雅氏病之后，法国开展了一项流行病学调查。自1959年法国开始hGH治疗起，至1985年8月调查开始之日，共有1698名患者登记接受治疗。获取了1620名患者（95.4%）的近期信息（距今不到3个月）。报告有31名患者死亡，但均与克雅氏病或类似疾病无关。在213名在世患者（13.1%）中观察到病理性事件。其中，4例疾病归类为可能与病毒感染有关。第一例患有急性淋巴细胞白血病；第二例患有与肝炎相关的多发性神经根神经炎。两例疾病均完全康复。另外两名患者在治疗开始后不到两年发生急性脑炎，且均自行康复。尽管急性病程和临床自发恢复与克雅氏病不符，但不能完全排除与hGH治疗的相关性。最后，5名接受治疗的儿童后来发生恶性肿瘤，这引发了hGH对细胞增殖的长期继发效应问题。
