血液 mSEPT9 的定量分析可确定结直肠肿瘤的检测性能。
The quantitative profiling of blood mSEPT9 determines the detection performance on colorectal tumors.
机构信息
Department of Radiotherapy, the Chinese PLA 309th Hospital, Beijing, PR China.
BioChain (Beijing) Science & Technology, Inc., Beijing, PR China.
出版信息
Epigenomics. 2018 Dec;10(12):1569-1583. doi: 10.2217/epi-2017-0154. Epub 2018 Nov 14.
AIM
To investigate the quantitative relationship between the positive detection rate (PDR) in colorectal tumor detection and the mSEPT9 level.
MATERIALS & METHODS: The level of blood mSEPT9 in various colorectal diseases was quantified by the Epi proColon 2.0 assay. ΔΔCt values were calculated representing the mSEPT9 level. A total of 1347 subjects were recruited in this quantitative study.
RESULTS
PDR or sensitivity was positively correlated with the progression of colorectal tumors and the mSEPT9 level in an exponential relationship. The mSEPT9 level of CRC exhibited a distinct pattern of distribution. Strong correlation was found between mSEPT9 level and PDR or sensitivity in various tumor differentiation, pathological types or metastasis.
CONCLUSION
The quantitative profiling of blood mSEPT9 determines the detection performance on colorectal tumors.
目的
研究结直肠肿瘤检测中阳性检出率（PDR）与 mSEPT9 水平之间的定量关系。
材料与方法
采用 Epi proColon 2.0 检测法对各种结直肠疾病的血液 mSEPT9 水平进行定量，计算 ΔΔCt 值表示 mSEPT9 水平。本定量研究共纳入 1347 例受试者。
结果
PDR 或灵敏度与结直肠肿瘤的进展和 mSEPT9 水平呈指数关系正相关。CRC 的 mSEPT9 水平呈现出明显的分布模式。mSEPT9 水平与各种肿瘤分化、病理类型或转移的 PDR 或灵敏度之间存在很强的相关性。
结论
血液 mSEPT9 的定量分析可确定其对结直肠肿瘤的检测性能。
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