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Effect of 2 Psoriasis Treatments on Vascular Inflammation and Novel Inflammatory Cardiovascular Biomarkers: A Randomized Placebo-Controlled Trial.两种银屑病治疗方法对血管炎症和新型炎症性心血管生物标志物的影响：一项随机安慰剂对照试验。
Circ Cardiovasc Imaging. 2018 Jun;11(6):e007394. doi: 10.1161/CIRCIMAGING.117.007394.
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From clinical observations to molecular mechanisms and back to patients: the successful circuit of the CANTOS study.从临床观察到分子机制，再回归患者：CANTOS研究的成功循环。
Cardiovasc Res. 2018 Jan 1;114(1):e3-e5. doi: 10.1093/cvr/cvx219.
3
JAK inhibition as a therapeutic strategy for immune and inflammatory diseases.JAK 抑制作为治疗免疫和炎症性疾病的策略。
Nat Rev Drug Discov. 2017 Dec;16(12):843-862. doi: 10.1038/nrd.2017.201. Epub 2017 Nov 6.
4
Reduction of Inflammatory and Cardiovascular Proteins in the Blood of Patients with Psoriasis: Differential Responses between Tofacitinib and Etanercept after 4 Weeks of Treatment.银屑病患者血液中炎症和心血管蛋白的减少：治疗 4 周后托法替尼和依那西普的差异反应。
J Invest Dermatol. 2018 Feb;138(2):273-281. doi: 10.1016/j.jid.2017.08.040. Epub 2017 Sep 18.
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Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.卡那奴单抗治疗动脉粥样硬化疾病的抗炎疗法。
N Engl J Med. 2017 Sep 21;377(12):1119-1131. doi: 10.1056/NEJMoa1707914. Epub 2017 Aug 27.
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Effect of tofacitinib on lipid levels and lipid-related parameters in patients with moderate to severe psoriasis.托法替布对中重度银屑病患者血脂水平及血脂相关参数的影响。
J Clin Lipidol. 2017 Sep-Oct;11(5):1243-1256. doi: 10.1016/j.jacl.2017.06.012. Epub 2017 Jun 24.
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The emerging safety profile of JAK inhibitors in rheumatic disease.新型 JAK 抑制剂在风湿性疾病中的安全性概况。
Nat Rev Rheumatol. 2017 Apr;13(4):234-243. doi: 10.1038/nrrheum.2017.23. Epub 2017 Mar 2.
8
Effects of Baricitinib on Lipid, Apolipoprotein, and Lipoprotein Particle Profiles in a Phase IIb Study of Patients With Active Rheumatoid Arthritis.巴瑞替尼对活动期类风湿关节炎患者的血脂、载脂蛋白和脂蛋白颗粒谱的影响：一项 IIb 期研究。
Arthritis Rheumatol. 2017 May;69(5):943-952. doi: 10.1002/art.40036.
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Psoriasis.银屑病。
Nat Rev Dis Primers. 2016 Nov 24;2:16082. doi: 10.1038/nrdp.2016.82.
10
Effects of tofacitinib on cardiovascular risk factors and cardiovascular outcomes based on phase III and long-term extension data in patients with plaque psoriasis.基于斑块型银屑病患者的 III 期和长期扩展数据，评估托法替尼对心血管危险因素和心血管结局的影响。
J Am Acad Dermatol. 2016 Nov;75(5):897-905. doi: 10.1016/j.jaad.2016.06.012. Epub 2016 Aug 4.

Potential cardiovascular implications of Janus kinase inhibitors in immune mediated diseases.

作者信息

Mehta Nehal N

机构信息

Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Clinical Research Center, Room 5-5140, Bethesda, USA.

出版信息

Cardiovasc Res. 2018 Sep 1;114(11):e81-e83. doi: 10.1093/cvr/cvy160.

DOI:10.1093/cvr/cvy160
PMID:30428019
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6106098/
Abstract
摘要