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与角质形成细胞共生。

Living with Keratinocytes.

机构信息

Center for Regenerative Medicine "Stefano Ferrari", Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Center for Regenerative Medicine "Stefano Ferrari", Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.

出版信息

Stem Cell Reports. 2018 Nov 13;11(5):1026-1033. doi: 10.1016/j.stemcr.2018.10.005.

Abstract

A feature distinguishing human hematopoietic and epithelial stem cells from other equally fascinating stem cells is perhaps their easier translation into a clinical setting. We have devoted nearly our entire scientific career in trying to turn our understanding of epithelial stem cell biology into something that could help people suffering from virtually untreatable diseases of squamous epithelia. We have done that as a team, together with our numerous students, postdocs, technicians and valuable collaborators, clinicians, regulators, and, lately, industrial partners. We had rewarding successes and burning failures, but we always did our best. This award, given by friends and colleagues deserving it more than us, has been the most important recognition of our work. Below, we summarize our story.

摘要

一个将人类造血干细胞和上皮干细胞与其他同样引人入胜的干细胞区分开来的特征,也许是它们更容易转化为临床环境。我们几乎将整个科研生涯都致力于将对上皮干细胞生物学的理解转化为能够帮助患有鳞状上皮几乎无法治疗的疾病的人们的东西。我们作为一个团队,与我们众多的学生、博士后、技术人员和有价值的合作者、临床医生、监管机构,以及最近的工业合作伙伴一起做到了这一点。我们取得了丰硕的成功和惨痛的失败,但我们始终尽了最大的努力。这个奖项是由比我们更值得的朋友和同事授予的,这是对我们工作的最重要认可。下面,我们总结一下我们的故事。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25f1/6235013/4e85ba78c905/gr1.jpg

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