Tariot P N, Gross M, Sunderland T, Cohen M R, Weingartner H, Murphy D L, Cohen R M
Psychiatry Unit, Monroe Community Hospital, Rochester, New York 14603.
J Am Geriatr Soc. 1988 Aug;36(8):681-6. doi: 10.1111/j.1532-5415.1988.tb07168.x.
The behavioral and cognitive effects of naloxone HCl, in doses of 5 micrograms/kg, 0.1 mg/kg, and 2.0 mg/kg administered as an IV bolus, were assessed in a double-blind, placebo-controlled, randomized study of eight normal subjects ranging in age from 44 to 74 years (mean 63). Naloxone produced mild behavioral effects with slight cognitive impairment after the 2.0 mg/kg dose only. The threshold, dose dependency, characteristics, and magnitude of these behavioral effects were similar to what has previously been reported in young normal subjects, but markedly different from those observed in patients with dementia of the Alzheimer type (DAT) matched in age to the current study sample. These data suggest that the metabolic fate of naloxone is not substantially affected by age within the range studied. The findings of this study provide further support for a role for endogenous opiate systems in the modulation of behavior and cognition, and suggest that the unusual behavioral sensitivity of patients with DAT to naloxone cannot be accounted for by the effect of age.
在一项针对8名年龄在44至74岁（平均63岁）的正常受试者的双盲、安慰剂对照、随机研究中，评估了静脉推注剂量为5微克/千克、0.1毫克/千克和2.0毫克/千克的盐酸纳洛酮的行为和认知效应。仅在2.0毫克/千克剂量后，纳洛酮产生了轻微的行为效应并伴有轻微的认知障碍。这些行为效应的阈值、剂量依赖性、特征和程度与先前在年轻正常受试者中报告的情况相似，但与在年龄与当前研究样本匹配的阿尔茨海默型痴呆（DAT）患者中观察到的情况明显不同。这些数据表明，在所研究的年龄范围内，纳洛酮的代谢命运基本不受年龄影响。本研究结果进一步支持内源性阿片系统在行为和认知调节中的作用，并表明DAT患者对纳洛酮异常的行为敏感性不能用年龄效应来解释。
