Nutt J G
Department of Neurology, Oregon Health Sciences University, Portland.
J Neural Transm Suppl. 1988;27:11-5. doi: 10.1007/978-3-7091-8954-2_2.
Delivery of levodopa or other dopaminergic agents to the striatum is a critical determinant of the clinical response and may account for many of the fluctations in response ("on-off"). This should be manageable with innovative delivery systems for the drugs. However further studies are required to determine if continuous dopaminergic stimulation will be complicated by increased levels of drug metabolites or down regulation of dopaminergic neurotransmission.
左旋多巴或其他多巴胺能药物向纹状体的递送是临床反应的关键决定因素，可能是导致许多反应波动（“开-关”现象）的原因。这可以通过创新的药物递送系统来控制。然而，需要进一步研究以确定持续的多巴胺能刺激是否会因药物代谢物水平升高或多巴胺能神经传递的下调而变得复杂。
