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1
Anthelmintics - From Discovery to Resistance III (Indian Rocks Beach, FL, 2018).驱虫剂——从发现到耐药性 III(2018 年,佛罗里达州印第安礁海滩)。
Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):494-495. doi: 10.1016/j.ijpddr.2018.11.002. Epub 2018 Nov 5.
2
Anthelmintics: From discovery to resistance II (San Diego, 2016).驱虫药:从发现到抗药性 II(圣地亚哥,2016 年)
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Anthelmintics - from discovery to resistance.驱虫药——从发现到抗药性
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Mechanism-based screening: discovery of the next generation of anthelmintics depends upon more basic research.基于机制的筛选:下一代驱虫药的发现依赖于更多的基础研究。
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6
Anthelmintics and ion-channels: after a puncture, use a patch.驱虫药与离子通道:穿刺后,使用贴片。
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The Validation of Nematode-Specific Acetylcholine-Gated Chloride Channels as Potential Anthelmintic Drug Targets.线虫特异性乙酰胆碱门控氯离子通道作为潜在抗蠕虫药物靶点的验证
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8
The antitrypanosomal diarylamidines, diminazene and pentamidine, show anthelmintic activity against Haemonchus contortus in vitro.抗锥虫二芳基脒类药物,地美硝唑和喷他脒,在体外对捻转血矛线虫显示出驱虫活性。
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本文引用的文献

1
TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling.三磷酸对甲苯磺酸盐,一种单一的、口服的杀血吸虫前药:体内疗效、处置和代谢特征。
Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):571-586. doi: 10.1016/j.ijpddr.2018.10.004. Epub 2018 Nov 20.
2
Anthelmintic drug actions in resistant and susceptible C. elegans revealed by electrophysiological recordings in a multichannel microfluidic device.利用多通道微流控装置中的电生理记录揭示耐药和敏感秀丽隐杆线虫中的驱虫药物作用。
Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):607-628. doi: 10.1016/j.ijpddr.2018.10.003. Epub 2018 Oct 30.
3
Nicotine-sensitive acetylcholine receptors are relevant pharmacological targets for the control of multidrug resistant parasitic nematodes.尼古丁敏感型乙酰胆碱受体是控制多药耐药寄生线虫的相关药理学靶点。
Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):540-549. doi: 10.1016/j.ijpddr.2018.11.003. Epub 2018 Nov 20.
4
Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni.结合生物信息学、化学信息学、功能基因组学和整体生物方法鉴定曼氏血吸虫中的表观遗传药物靶点。
Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):559-570. doi: 10.1016/j.ijpddr.2018.10.005. Epub 2018 Nov 13.
5
Investigating the function and possible biological role of an acetylcholine-gated chloride channel subunit (ACC-1) from the parasitic nematode Haemonchus contortus.研究寄生性线虫捻转血矛线虫(Haemonchus contortus)中的乙酰胆碱门控氯离子通道亚基(ACC-1)的功能和可能的生物学作用。
Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):526-533. doi: 10.1016/j.ijpddr.2018.10.010. Epub 2018 Oct 27.
6
Terror in the dirt: Sensory determinants of host seeking in soil-transmitted mammalian-parasitic nematodes.藏身泥土中的恐惧:土壤传播的哺乳动物寄生线虫寻找宿主的感觉决定因素。
Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):496-510. doi: 10.1016/j.ijpddr.2018.10.008. Epub 2018 Oct 26.
7
A mutational and molecular dynamics study of the cys-loop GABA receptor Hco-UNC-49 from Haemonchus contortus: Agonist recognition in the nematode GABA receptor family.半胱氨酸环配体门控 GABA 受体 Hco-UNC-49 的突变和分子动力学研究:线虫 GABA 受体家族中的激动剂识别。
Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):534-539. doi: 10.1016/j.ijpddr.2018.10.001. Epub 2018 Oct 6.
8
Structure-activity profiling of alkaloid natural product pharmacophores against a Schistosoma serotonin receptor.生物碱天然产物药效团对血吸虫 5-羟色胺受体的构效关系分析。
Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):550-558. doi: 10.1016/j.ijpddr.2018.09.001. Epub 2018 Sep 28.
9
Recognition and killing of Brugia malayi microfilariae by human immune cells is dependent on the parasite sample and is not altered by ivermectin treatment.人体免疫细胞识别和杀死马来丝虫微丝蚴依赖于寄生虫样本,而伊维菌素治疗不会改变这种情况。
Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):587-595. doi: 10.1016/j.ijpddr.2018.09.002. Epub 2018 Sep 22.
10
Molecular and pharmacological characterization of an acetylcholine-gated chloride channel (ACC-2) from the parasitic nematode Haemonchus contortus.寄生性线虫旋毛虫(Haemonchus contortus)乙酰胆碱门控氯离子通道(ACC-2)的分子和药理学特性。
Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):518-525. doi: 10.1016/j.ijpddr.2018.09.004. Epub 2018 Sep 22.

驱虫剂——从发现到耐药性 III(2018 年,佛罗里达州印第安礁海滩)。

Anthelmintics - From Discovery to Resistance III (Indian Rocks Beach, FL, 2018).

机构信息

Department of Infectious Diseases, University of Georgia, Athens, GA, 30602, USA.

Department of Biomedical Sciences, Iowa State University, Ames, IA, 50011, USA.

出版信息

Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):494-495. doi: 10.1016/j.ijpddr.2018.11.002. Epub 2018 Nov 5.

DOI:10.1016/j.ijpddr.2018.11.002
PMID:30429103
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6287533/
Abstract

The third scientific meeting in the series "Anthelmintics: From Discovery to Resistance" was held in Indian Rocks Beach, Florida, at the end of January 2018. The meeting focused on a variety of topics related to the title, including the identification of novel targets and new leads, the mechanism of action of existing drugs and the genetic basis of resistance against them. Throughout there was an emphasis on the exploitation of new technologies and methods to further these aims. The presentations, oral and poster, covered basic, veterinary and medical science with strong participation by both academic and commercial researchers. This special issue contains selected papers from the meeting.

摘要

2018 年 1 月底,在佛罗里达州印第安礁海滩举行了系列研讨会“驱虫剂:从发现到耐药性”的第三次科学会议。会议重点讨论了与标题相关的各种主题,包括新型靶标和新先导物的鉴定、现有药物的作用机制以及对它们的耐药性的遗传基础。整个会议强调利用新技术和方法来进一步实现这些目标。演讲和海报涵盖了基础、兽医和医学科学,学术和商业研究人员都积极参与。本期特刊包含会议的精选论文。