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人类早期母胎界面的单细胞重建。

Single-cell reconstruction of the early maternal-fetal interface in humans.

机构信息

Wellcome Sanger Institute, Cambridge, UK.

Centre for Trophoblast Research, University of Cambridge, Cambridge, UK.

出版信息

Nature. 2018 Nov;563(7731):347-353. doi: 10.1038/s41586-018-0698-6. Epub 2018 Nov 14.

DOI:10.1038/s41586-018-0698-6
PMID:30429548
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7612850/
Abstract

During early human pregnancy the uterine mucosa transforms into the decidua, into which the fetal placenta implants and where placental trophoblast cells intermingle and communicate with maternal cells. Trophoblast-decidual interactions underlie common diseases of pregnancy, including pre-eclampsia and stillbirth. Here we profile the transcriptomes of about 70,000 single cells from first-trimester placentas with matched maternal blood and decidual cells. The cellular composition of human decidua reveals subsets of perivascular and stromal cells that are located in distinct decidual layers. There are three major subsets of decidual natural killer cells that have distinctive immunomodulatory and chemokine profiles. We develop a repository of ligand-receptor complexes and a statistical tool to predict the cell-type specificity of cell-cell communication via these molecular interactions. Our data identify many regulatory interactions that prevent harmful innate or adaptive immune responses in this environment. Our single-cell atlas of the maternal-fetal interface reveals the cellular organization of the decidua and placenta, and the interactions that are critical for placentation and reproductive success.

摘要

在人类妊娠早期，子宫黏膜会转变为蜕膜，胎儿胎盘就植入在蜕膜中，胎盘滋养细胞会与母体细胞混合并相互交流。滋养细胞-蜕膜的相互作用是妊娠相关常见疾病（包括子痫前期和死胎）的基础。在这里，我们对来自妊娠早期胎盘的约 70,000 个单细胞以及匹配的母体血液和蜕膜细胞进行了转录组分析。人类蜕膜的细胞组成揭示了位于不同蜕膜层的血管周细胞和基质细胞亚群。蜕膜自然杀伤细胞有三个主要亚群，它们具有独特的免疫调节和趋化因子特征。我们构建了配体-受体复合物库，并开发了一种统计工具，通过这些分子相互作用来预测细胞间通讯的细胞类型特异性。我们的数据确定了许多调节性相互作用，这些相互作用可以防止在这种环境中产生有害的固有或适应性免疫反应。我们对母体-胎儿界面的单细胞图谱揭示了蜕膜和胎盘的细胞组织，以及对胎盘形成和生殖成功至关重要的相互作用。

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2
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Cell Res. 2018 Aug;28(8):819-832. doi: 10.1038/s41422-018-0066-y. Epub 2018 Jul 24.
3
Trained Memory of Human Uterine NK Cells Enhances Their Function in Subsequent Pregnancies.
一种基于诱导多能干细胞的体外模型概括了人类胸腺上皮发育和多谱系分化。
Nat Commun. 2025 Aug 25;16(1):7680. doi: 10.1038/s41467-025-62523-1.
4
Boosting data interpretation with GIBOOST to enhance visualization of complex high-dimensional data.使用GIBOOST增强数据解释，以提升复杂高维数据的可视化效果。
Brief Bioinform. 2025 Jul 2;26(4). doi: 10.1093/bib/bbaf415.
5
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6
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Genes Dis. 2025 May 2;12(6):101665. doi: 10.1016/j.gendis.2025.101665. eCollection 2025 Nov.
7
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