添加透明质酸至缝合材料的效果及其与细菌定植的关系：一项研究。
Effect of Hyaluronic Acid Added to Suture Material and its Relationship with Bacterial Colonization: An Study.
作者信息
Sudhir Varma Rama, Biju Thomas, Ramesh Amitha, Ergieg Suleiman, Fanas Salim Abou, Desai Vijay, Mohammed Afrah Aldhanhani, Ahmed Malaz Abdulaziz
机构信息
Department of Periodontics, Ajman University, Ajman, UAE.
Department of Periodontics, ABSMIDS, Mangalore, Karnataka, India.
出版信息
J Int Soc Prev Community Dent. 2018 Sep-Oct;8(5):391-395. doi: 10.4103/jispcd.JISPCD_222_18. Epub 2018 Sep 6.
AIMS AND OBJECTIVES
The aims of this study were to evaluate the presence of and , in polyglycolic acid (PGA) 4-0 and silk sutures, with or without hyaluronic acid (HA) treatment.
MATERIALS AND METHODS
This study measured and growth on PGA and silk sutures, through incubation in agar media for 24 h. The suture length was 10 cm and divided into three parts: A (8 h), B (16 h), and C (24 h), which were observed every 8 h, followed by suspension on a microscopic slide. This was repeated thrice. The number of and cells was recorded and compared between the suture types.
RESULTS
The mean colony forming units (CFUs) differed at each time point between non-HA and HA-PGA sutures ( = 0.0016), with a greater number of CFUs on non-HA-PGA. The mean CFUs were significantly higher on non-HA silk than on HA-silk sutures ( = 0.008). There was a significant increase in CFUs on non-HA silk than on HA-silk sutures ( = 0.008). CFUs were higher on non-HA-PGA than on HA-PGA sutures ( = 0.006). We performed repeated measures two-way ANOVA (SPSS version 13.0) for comparison between group factors and time points and analysis using independent samples -test.
CONCLUSIONS
HA reduced wicking in both PGA and silk sutures.
目的与目标
本研究的目的是评估聚乙醇酸（PGA）4-0缝线和丝线在有无透明质酸（HA）处理情况下的[具体物质1]和[具体物质2]的存在情况。
材料与方法
本研究通过在琼脂培养基中孵育24小时，测量[具体物质1]和[具体物质2]在PGA缝线和丝线中的生长情况。缝线长度为10厘米，分为三个部分：A（8小时）、B（16小时）和C（24小时），每8小时观察一次，随后置于载玻片上。此过程重复三次。记录缝线类型之间的[具体物质1]和[具体物质2]细胞数量并进行比较。
结果
非HA和HA-PGA缝线在每个时间点的平均[具体物质1]菌落形成单位（CFU）不同（P = 0.0016），非HA-PGA上的CFU数量更多。非HA丝线的平均[具体物质2]CFU显著高于HA-丝线缝线（P = 0.008）。非HA丝线上的[具体物质2]CFU比HA-丝线上的显著增加（P = 0.008）。非HA-PGA上的[具体物质2]CFU高于HA-PGA缝线（P = 0.006）。我们使用重复测量双向方差分析（SPSS 13.0版）比较组因素和时间点，并使用独立样本t检验进行分析。
结论
HA减少了PGA缝线和丝线中的毛细作用。
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