Second Department of Gynecology & Obstetrics, Faculty of Medicine, Comenius University of Bratislava, 82606 Bratislava, Slovakia.
Alpha Medical Pathology, Ltd, 84101 Bratislava, Slovakia.
Nanomedicine (Lond). 2018 Dec;13(24):3075-3081. doi: 10.2217/nnm-2018-0220. Epub 2018 Nov 15.
In this study we used a new technology for localization of non-palpable breast tumors using a small steel marker in conjunction of sentinel nodes (SLNs) detection through injection of SPIO nanoparticles; both detected through a magnetic probe. Materials & methods: Ten patients with biopsy-proven nonpalpable invasive breast carcinoma or premalignant lesions eligible for SLNs biopsy were enrolled in this study.
All tumors were removed with safe surgical margins. The mean nodal detection rate was 3.4 nodes per patient. No interferences in magnetic probe measurements due to the presence of both markers in the same breast were observed.
Simultaneous use of the magnetic method in localization of impalpable breast tumors and SNs detection makes breast surgery convenient.
本研究使用一种新的技术,通过注射超顺磁氧化铁纳米颗粒,结合小钢标记物定位触诊阴性乳腺肿瘤,同时通过磁探针检测前哨淋巴结(SLN)。材料与方法:本研究纳入了 10 例经活检证实的触诊阴性浸润性乳腺癌或癌前病变患者,适合进行 SLN 活检。结果:所有肿瘤均安全切缘切除。平均每个患者检测到 3.4 个淋巴结。在同一乳房中同时存在这两种标记物时,没有观察到对磁探针测量的干扰。结论:触诊阴性乳腺肿瘤的磁性定位和前哨淋巴结检测的同时使用使乳腺手术更加方便。