Diaz-Abad Montserrat, Buczyner Jennifer R, Venza Brigit R, Scharf Steven M, Kwan Justin Y, Lubinski Brooke, Russell James W
Department of Medicine, University of Maryland, Baltimore, MD.
Comprehensive Neurology of the Palm Beaches, Palm Beach Gardens, FL.
J Clin Neuromuscul Dis. 2018 Dec;20(2):60-68. doi: 10.1097/CND.0000000000000234.
Patients with amyotrophic lateral sclerosis (ALS) have poor sleep quality, but little is known about which factors affect sleep at time of diagnosis.
Patients with newly diagnosed ALS were administered the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale, Beck Depression Inventory-Revised, and ALS Functional Rating Scale and were compared with controls.
Forty-three patients, age 63.8 ± 11.5 years, ALS Functional Rating Scale 30.7 ± 5.0. Poor sleep quality was frequent: 27 (63%) patients had PSQI >5 compared with 16 (37%) controls (P = 0.031); with higher PSQI (7.1 ± 4.1 vs. 4.7 ± 2.8, P = 0.003). PSQI correlated with Beck Depression Inventory-Revised (r = 0.344, P = 0.024) and inability to turn in bed (r = -0.335, P = 0.033).
Patients with newly diagnosed ALS have poor sleep quality, which is associated with depression and difficulty turning in bed. Longitudinal studies to examine the evolution of sleep quality and the effectiveness of individualized interventions are needed in patients with ALS.
肌萎缩侧索硬化症（ALS）患者睡眠质量较差，但在诊断时哪些因素会影响睡眠却知之甚少。
对新诊断的ALS患者进行匹兹堡睡眠质量指数（PSQI）、爱泼华嗜睡量表、贝克抑郁量表修订版和ALS功能评定量表评估，并与对照组进行比较。
43例患者，年龄63.8±11.5岁，ALS功能评定量表评分为30.7±5.0。睡眠质量差很常见：27例（63%）患者PSQI>5，而对照组为16例（37%）（P=0.031）；PSQI更高（7.1±4.1对4.7±2.8，P=0.003）。PSQI与贝克抑郁量表修订版（r=0.344，P=0.024）及无法在床上翻身（r=-0.335，P=0.033）相关。
新诊断的ALS患者睡眠质量较差，这与抑郁及在床上翻身困难有关。需要对ALS患者进行纵向研究，以检查睡眠质量的演变及个体化干预的效果。
