Holmberg G
Karolinska Institute, Stockholm, Sweden.
Acta Psychiatr Scand. 1988 May;77(5):584-6. doi: 10.1111/j.1600-0447.1988.tb05171.x.
By means of critical flicker fusion measurements and subjective estimation of drowsiness, experiments with 12 healthy subjects over periods of 8 h showed that maprotiline caused less than half the amount of sedation compared to amitriptyline, both drugs given in single doses of 50 mg. The experiments were blind, randomized and placebo controlled. Implications for clinical use are discussed.
通过临界闪烁融合测量和嗜睡的主观评估，对12名健康受试者进行的长达8小时的实验表明，与阿米替林相比，单剂量服用50毫克的马普替林引起的镇静作用不到其一半。实验采用双盲、随机和安慰剂对照设计。文中还讨论了该研究结果对临床应用的启示。
