Tanaka Kazutoshi, Takao Hiroyuki, Suzuki Takashi, Fujimura Soichiro, Uchiyama Yuya, Otani Katharina, Ishibashi Toshihiro, Mamori Hiroya, Fukudome Koji, Yamamoto Makoto, Murayama Yuichi
Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:1347-1350. doi: 10.1109/EMBC.2018.8512466.
Research on the relationship between cerebralaneurysm initiation and hemodynamic parameters, but several open questions remain on initiation and growth mechanisms of cerebral aneurysms. If factors contributing to initiation were identified, it would be possible to predict the initiation of aneurysms. The purpose of this study is to investigate the relationship between cerebral aneurysm initiation and hemodynamic factors. Blood flow simulations in aneurysms of three patients were performed using computational fluid dynamics (CFD) based on the cerebral blood vessel geometry before aneurysm initiation. We evaluated pressure, wall shear stress (WSS), wall shear stress gradient (WSSG), oscillatory shear index (OSI) and gradient oscillatory number (GON) since these factors are known to be associated with aneurysmal initiation. We also focused on the wall shear stress divergence (WSSD) in particular on the direction of WSS. Our results indicated that only high WSSD regions corresponded to the initiation regions, and the value of WSSD was remarkably high. Stretching force to the vessel wall may be related to the initiation of cerebral aneurysms.
关于脑动脉瘤起始与血流动力学参数之间关系的研究，但在脑动脉瘤的起始和生长机制方面仍存在一些未解决的问题。如果能够确定促成起始的因素，就有可能预测动脉瘤的起始。本研究的目的是探讨脑动脉瘤起始与血流动力学因素之间的关系。基于动脉瘤起始前的脑血管几何形状，使用计算流体动力学（CFD）对三名患者的动脉瘤进行了血流模拟。我们评估了压力、壁面切应力（WSS）、壁面切应力梯度（WSSG）、振荡切应力指数（OSI）和梯度振荡数（GON），因为已知这些因素与动脉瘤的起始有关。我们还特别关注壁面切应力散度（WSSD），尤其是WSS的方向。我们的结果表明，只有高WSSD区域与起始区域相对应，且WSSD的值非常高。作用于血管壁的拉伸力可能与脑动脉瘤的起始有关。
