Relationship between hemodynamic parameters and cerebral aneurysm initiation.

Research on the relationship between cerebralaneurysm initiation and hemodynamic parameters, but several open questions remain on initiation and growth mechanisms of cerebral aneurysms. If factors contributing to initiation were identified, it would be possible to predict the initiation of aneurysms. The purpose of this study is to investigate the relationship between cerebral aneurysm initiation and hemodynamic factors. Blood flow simulations in aneurysms of three patients were performed using computational fluid dynamics (CFD) based on the cerebral blood vessel geometry before aneurysm initiation. We evaluated pressure, wall shear stress (WSS), wall shear stress gradient (WSSG), oscillatory shear index (OSI) and gradient oscillatory number (GON) since these factors are known to be associated with aneurysmal initiation. We also focused on the wall shear stress divergence (WSSD) in particular on the direction of WSS. Our results indicated that only high WSSD regions corresponded to the initiation regions, and the value of WSSD was remarkably high. Stretching force to the vessel wall may be related to the initiation of cerebral aneurysms.