Bernardinis Matthew, Atashzar Seyed Farokh, Jog Mandar, Patel Rajni V
Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:2748-2751. doi: 10.1109/EMBC.2018.8512754.
Parkinson's Disease (PD) is typically classified by the onset of motor impairments, however, non-motor symptoms are also present in all disease stages. Vision abnormalities contribute to the non-motor PD deficits, yet little research has studied how PD affects visual perceptions with no produced motor responses. This provides motivation for the current study which focuses on examining allocentric visual displacement perception - information used for object identification - in PD patients. To study this PD participants OFF and ON Levodopa therapy, and age-matched healthy control participants were tested. A modular graphics toolbox was implemented to carry out the perceptual testing. Individuals with PD were shown to have impairments in displacement perception of the larger tested magnitudes when both OFF and ON Levodopa compared to control participants, suggesting impairments in visual displacement processing pathways. These abnormalities could contribute to difficulties some PD patients have with visual recognition and visuospatial navigation. Furthermore, the study validated the graphical tool as a means of quantifying perceptual abilities that can be expanded to many perceptual modalities and paired with robotic devices.
帕金森病（PD）通常根据运动障碍的发作进行分类，然而，非运动症状在疾病的所有阶段也都存在。视觉异常导致了非运动性PD缺陷，但很少有研究探讨PD如何在没有产生运动反应的情况下影响视觉感知。这为当前的研究提供了动力，该研究专注于检查PD患者的以客体为中心的视觉位移感知——用于物体识别的信息。为了研究这一点，对接受左旋多巴治疗的PD参与者和年龄匹配的健康对照参与者进行了测试。使用了一个模块化图形工具箱来进行感知测试。结果显示，与对照参与者相比，无论是在停用还是使用左旋多巴的情况下，PD患者在较大测试幅度的位移感知方面都存在障碍，这表明视觉位移处理通路存在障碍。这些异常可能导致一些PD患者在视觉识别和视觉空间导航方面出现困难。此外，该研究验证了图形工具作为一种量化感知能力的手段，这种能力可以扩展到许多感知模态，并与机器人设备配合使用。
