Armelagos G J, Chrisman O D
Department of Anthropology, University of Massachusetts, Amherst.
Am J Phys Anthropol. 1988 May;76(1):25-8. doi: 10.1002/ajpa.1330760103.
The aim of this article is to present evidence of hyperostosis frontalis interna in a 40-year-old female recovered from a Meroitic cemetery (ca. 300 A.D.) in Sudanese Nubia. A review of the literature concerning the Morgagni-Stewart-Morel (MSM) syndrome suggests that the changes in the skull fragment are consistent with this diagnosis. This case is the earliest example of the condition so far reported, and therefore, in archaeological time and space, this is a disease not only of modern civilization, but also of antiquity. Current endocrinological reports suggest that the hyperostosis is the hallmark of a generalized disorder of bone metabolism, with increased androgens, prolactin, and somatotropins. Hyperostosis frontalis interna is the central feature of a syndrome first described over 200 years ago by the early pathologist Giovanni Batistta Morgagni, professor of anatomy at Padua (1719). He found thickening of the internal tables of the frontal bones in association with virilism and obesity. Stewart (1928) and Morel (1929) independently added several neuropsychiatric problems to this complex and questioned the possibility of an endocrine basis for the syndrome.
本文旨在展示一名40岁女性的额骨内板增生证据，该女性遗体出土于苏丹努比亚地区一处麦罗埃墓地（约公元300年）。对有关莫尔加尼-斯图尔特-莫雷尔（MSM）综合征的文献综述表明，头骨碎片的变化与该诊断相符。该病例是迄今为止报道的该病最早的例子，因此，从考古时空角度来看，这是一种不仅存在于现代文明，也存在于古代的疾病。当前的内分泌学报告表明，骨增生是骨代谢普遍紊乱的标志，伴有雄激素、催乳素和生长激素水平升高。额骨内板增生是一种综合征的核心特征，该综合征于200多年前由帕多瓦解剖学教授、早期病理学家乔瓦尼·巴蒂斯塔·莫尔加尼（1719年）首次描述。他发现额骨内板增厚与男性化和肥胖有关。斯图尔特（1928年）和莫雷尔（1929年）分别在这一综合征中增加了一些神经精神问题，并对该综合征的内分泌基础可能性提出质疑。
