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混合多波长光声成像。

Hybrid multi-wavelength photoacoustic imaging.

作者信息

Duan Tingyang, Lan Hengrong, Zhong Hongtao, Zhou Meng, Zhang Ruochong, Gao Fei

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:4804-4807. doi: 10.1109/EMBC.2018.8513153.

DOI:10.1109/EMBC.2018.8513153

PMID:30441421

Abstract

Multi-wavelength photoacoustic (PA) imaging has been studied extensively to explore the spectroscopic absorption contrast of biological tissues. To generate strong PA signals, a high-power wavelength-tunable pulsed laser source has to be employed, which is bulky and quite expensive. In this paper, we propose a hybrid multi-wavelength PA imaging (hPAI) method based on combination of single-wavelength pulsed and multi-wavelength continuous-wave (CW) laser sources. By carefully controlling laser illumination sequence (pulse-CW-pulse), and extracting the PA signals' difference before and after heating of CW lasers, the optical absorption property of multi-wavelength CW lasers could be obtained. Compared with conventional PA imaging, the proposed hPAI shows much lower system cost due to the usage of single-wavelength pulsed laser and cheap CW lasers. Theoretical analysis and analytical model are presented in this paper, followed by proof-of-concept experimental results.

摘要

多波长光声（PA）成像已被广泛研究，以探索生物组织的光谱吸收对比度。为了产生强烈的光声信号，必须使用高功率波长可调谐脉冲激光源，这种光源体积庞大且相当昂贵。在本文中，我们提出了一种基于单波长脉冲和多波长连续波（CW）激光源组合的混合多波长光声成像（hPAI）方法。通过仔细控制激光照射序列（脉冲 - 连续波 - 脉冲），并提取连续波激光加热前后的光声信号差异，可以获得多波长连续波激光的光吸收特性。与传统的光声成像相比，由于使用了单波长脉冲激光和廉价的连续波激光，所提出的hPAI显示出低得多的系统成本。本文给出了理论分析和分析模型，随后是概念验证实验结果。