Duan Tingyang, Lan Hengrong, Zhong Hongtao, Zhou Meng, Zhang Ruochong, Gao Fei
Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:4792-4795. doi: 10.1109/EMBC.2018.8513136.
Photoacoustic imaging has been intensively studied in recent years, and many of the achievements have already been applied in important biomedical and clinical applications, e.g. spectroscopic photoacoustic imaging to extract functional and molecular information. However, spectroscopic photoacoustic imaging requires expensive and bulky tunable laser source, which severely hinder its further development towards portable device. In this paper, we propose a novel imaging method, named optical spectroscopic ultrasound displacement (OSUD) imaging, which enables optical spectroscopic imaging in deep scattering tissue using multiple low-cost continuous-wave laser sources and ultrasound imaging equipment. The principle of the OSUD imaging method will be introduced, and followed by preliminary experimental results. The OSUD imaging may provide another pathway to provide spectroscopic optical absorption contrast in deep scattering tissue beyond commonly used photoacoustic imaging.
近年来,光声成像受到了广泛研究,许多成果已应用于重要的生物医学和临床应用中,例如用于提取功能和分子信息的光谱光声成像。然而,光谱光声成像需要昂贵且笨重的可调谐激光源,这严重阻碍了其向便携式设备方向的进一步发展。在本文中,我们提出了一种新颖的成像方法,称为光学光谱超声位移(OSUD)成像,它能够使用多个低成本连续波激光源和超声成像设备在深度散射组织中进行光学光谱成像。将介绍OSUD成像方法的原理,随后给出初步实验结果。OSUD成像可能为在深度散射组织中提供光谱光吸收对比度提供另一条途径,这是常用光声成像之外的方法。
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