Calvo Mireia, Rolle Virginie Le, Romero Daniel, Behar Nathalie, Gomis Pedro, Mabo Philippe, Hernandez Alfredo I
Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:5458-5461. doi: 10.1109/EMBC.2018.8513536.
This paper proposes the integration and analysis of a mathematical model representing the cardiovascular system and its short-term autonomic response to head-up tilt (HUT) testing. A Latin Hypercube Sampling method was applied to design an optimal experimental space, including 19 model parameters coming from the cardiovascular and baroreflex control systems. Then, a global, variance-based sensitivity analysis was applied to quantity the effects of these parameters on heart rate and systolic blood pressure. Results highlight the relevant influence of the intrinsic heart rate and the sympathetic and parasympathetic baroreflex gains on heart rate regulation, as well as the impact of left ventricle diastolic parameters on systolic blood pressure. Moreover, a significant effect of right ventricle dynamics on blood pressure was noted. These results provide valuable information for the application of such an integrated model for the analysis of the autonomic mechanisms regulating the cardiovascular response induced by postural changes. In particular, they suggest a convenient set of parameters to be identified in a subject-specific manner.
本文提出了一种对代表心血管系统及其对头部倾斜（HUT）测试的短期自主反应的数学模型进行整合与分析的方法。采用拉丁超立方抽样方法设计了一个最优实验空间，其中包括来自心血管和压力反射控制系统的19个模型参数。然后，应用基于方差的全局敏感性分析来量化这些参数对心率和收缩压的影响。结果突出了固有心率以及交感和副交感压力反射增益对心率调节的相关影响，以及左心室舒张参数对收缩压的影响。此外，还注意到右心室动力学对血压有显著影响。这些结果为应用这种整合模型分析调节姿势变化引起的心血管反应的自主机制提供了有价值的信息。特别是，它们提出了一组便于以个体特异性方式确定的参数。
