Department of Thoracic Surgery, Mackay Memorial Hospital, Taipei, Taiwan.
Research Center of Sleep Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
J Headache Pain. 2018 Nov 15;19(1):111. doi: 10.1186/s10194-018-0944-1.
Several studies examined headaches as a symptom of brain neoplasms. Nevertheless, very few studies attempted to specifically evaluate the role of headaches as a risk factor. This study aimed to investigate the risk of migraine occurrence in the preceding years among patients diagnosed with brain tumors and unaffected controls.
Data were obtained from the Taiwan National Health Insurance Research Database. In total, 11,325 adults with a first-time brain tumor diagnosis were included as cases, together with 11,325 unaffected matched controls. Each individual was traced in the healthcare claims dataset for a prior diagnosis of migraines. Conditional logistic regressions were performed to calculate the odds ratio (OR) and the corresponding 95% confidence interval (CI) to present the association between brain tumors and having previously been diagnosed with migraines.
We found that among patients with and those without brain tumors, 554 (4.89%) and 235 (2.08%) individuals, respectively, were identified as having a prior migraine diagnosis. Compared to unaffected controls, patients with brain tumors experienced an independent 2.45-fold increased risk of having a prior migraine diagnosis. The risks were even higher among men (odds ratio (OR) = 3.04, 95% confidence interval (CI) = 2.29~ 4.04) and after patients who had received a prior migraine diagnosis within 3 years were excluded (OR = 1.91, 95% CI = 1.59~ 2.29).
This is the first report demonstrating the occurrence of brain tumors to be associated with a prior migraine history, for both men and women, in a population-based study.
多项研究探讨了头痛作为脑肿瘤的症状。然而，很少有研究试图专门评估头痛作为危险因素的作用。本研究旨在调查在诊断出脑肿瘤的患者和未受影响的对照组中，前几年偏头痛发生的风险。
数据来自台湾全民健康保险研究数据库。共纳入 11325 例首次诊断为脑肿瘤的成年人作为病例组，同时纳入 11325 例未受影响的匹配对照组。每个个体都在医疗保健理赔数据集进行偏头痛的先前诊断跟踪。采用条件逻辑回归计算优势比（OR）和相应的 95%置信区间（CI），以呈现脑肿瘤与先前诊断为偏头痛之间的关联。
我们发现，在有和没有脑肿瘤的患者中，分别有 554 例（4.89%）和 235 例（2.08%）患者被诊断为先前患有偏头痛。与未受影响的对照组相比，患有脑肿瘤的患者发生先前偏头痛诊断的风险独立增加了 2.45 倍。在男性（比值比（OR）=3.04，95%置信区间（CI）=2.294.04）和排除了在 3 年内有偏头痛病史的患者后（OR=1.91，95% CI=1.592.29），风险更高。
这是第一项在基于人群的研究中表明脑肿瘤的发生与男性和女性的先前偏头痛病史相关的报告。
