Whittingham S
Burnet Clinical Research Unit, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.
Ann Acad Med Singap. 1988 Apr;17(2):195-200.
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease in which the predominant autoantibodies are antinuclear antibodies (ANA) reactive with DNA and histones, and antibodies reactive with the non-histone extractable nuclear antigens (ENA), Sm and Ro. Racial differences demonstrable in predisposition to SLE are also evident in the prevalence of autoantibodies, the frequency of anti-Sm and anti-Ro being 2-4 times higher in Asians with SLE than in Caucasians with SLE. Autoantibodies have also played a role in the classification of lupus and the recognition of multisystem autoimmune diseases that fail to meet the classical criteria for the identification of patients with SLE but appear to be variants of lupus. Anti-Ro is a diagnostic marker for subacute cutaneous lupus, anti-(U1)RNP a marker for mixed connective tissue disease, antibodies to phospholipids a marker for the syndrome comprising stroke, fetal wastage, thromboembolism and thrombocytopenia and antibodies to histones a marker for lupus induced by the drugs hydralazine and procainamide. There is still no unaminity on whether these antibodies play an integral role in the disease process or whether they are "epiphenomena". The challenge for research in the 1980s is the understanding of the relationship of these antibodies to the pathogenesis of SLE.
系统性红斑狼疮（SLE）是一种多系统自身免疫性疾病，其中主要的自身抗体是与DNA和组蛋白反应的抗核抗体（ANA），以及与非组蛋白可提取核抗原（ENA）、Sm和Ro反应的抗体。SLE易感性方面可证明的种族差异在自身抗体的患病率中也很明显，患有SLE的亚洲人中抗Sm和抗Ro的频率比患有SLE的白种人高2至4倍。自身抗体在狼疮的分类以及对多系统自身免疫性疾病的认识中也发挥了作用，这些疾病不符合诊断SLE患者的经典标准，但似乎是狼疮的变体。抗Ro是亚急性皮肤型狼疮的诊断标志物，抗（U1）RNP是混合性结缔组织病的标志物，抗磷脂抗体是包括中风、胎儿丢失、血栓栓塞和血小板减少症的综合征的标志物，抗组蛋白抗体是由肼屈嗪和普鲁卡因胺药物引起的狼疮的标志物。关于这些抗体在疾病过程中是否起不可或缺的作用，或者它们是否是“附带现象”，目前仍没有定论。20世纪80年代研究面临的挑战是理解这些抗体与SLE发病机制之间的关系。
