Suzumori K, Yasui Y, Suzumori K, Yagami Y, Seki T
Dept. of Obstetrics and Gynecology, Nagoya City University.
Gan To Kagaku Ryoho. 1988 Aug;15(8):2251-6.
The BUN, serum creatinine, creatinine clearance and the urinary excretion of leucine aminopeptidase (LAP), alkaline phosphatase (ALP), beta 2-microglobulin (beta-m), and N-acetyl-beta-glucosaminidase (NAG), were measured in 21 gynecological cancer patients treated with CAPF (CPA + ADM + CDDP + 5-FU) to evaluate the sensitivity of these indices to renal tubular damage. After receiving CDDP almost all patients displayed an increase in excretion of beta-m but no urinary enzyme activities. However, NAG index (NAG activity/urinary creatinine) rose markedly in all patients. We concluded that NAG index is a valuable method in providing sensitive indices for detecting renal tubular damage caused by CDDP.
对21例接受CAPF（环磷酰胺+阿霉素+顺铂+5-氟尿嘧啶）治疗的妇科癌症患者，测定其血尿素氮、血清肌酐、肌酐清除率以及亮氨酸氨基肽酶（LAP）、碱性磷酸酶（ALP）、β2-微球蛋白（β-m）和N-乙酰-β-葡萄糖苷酶（NAG）的尿排泄量，以评估这些指标对肾小管损伤的敏感性。接受顺铂治疗后，几乎所有患者的β-m排泄量增加，但尿酶活性无变化。然而，所有患者的NAG指数（NAG活性/尿肌酐）均显著升高。我们得出结论，NAG指数是检测顺铂所致肾小管损伤的敏感指标的一种有价值的方法。
