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高密度养殖会延迟大西洋鲑（Salmo salar）的伤口愈合。

High fish density delays wound healing in Atlantic salmon (Salmo salar).

机构信息

University of Bergen, Postboks 7800, 5020, Bergen, Norway.

Nofima, Osloveien 1, 1430, Ås, Norway.

出版信息

Sci Rep. 2018 Nov 15;8(1):16907. doi: 10.1038/s41598-018-35002-5.

DOI:10.1038/s41598-018-35002-5
PMID:30443022
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6237775/
Abstract

In this study, we look closer at how high fish densities influence wound repair mechanisms in post-smolt Atlantic salmon. The fish were wounded with a 5 mm skin punch biopsy needle and stocked at two different densities, a high fish density (100 kg/m) treatment and a low fish density treatment (20 kg/m) serving as the control. The healing wounds were followed for 57 days with samples taken 1, 3, 7, 14, 36, 43 and 57 days post wounding. The transcriptomic analysis suggests that high fish density enhance inflammation and represses cell proliferation, tissue secretion and collagen synthesis in the healing wounds. The histological analysis further showed delayed epidermal and dermal repair in the high fish density treatment compared to control. The overall wound contraction was also altered by the treatment. In conclusion, high fish density enhances immune responses and delay tissue repair, which ultimately results in delayed wound healing.

摘要

在这项研究中，我们更深入地研究了高密度鱼类如何影响大西洋鲑鱼亚成鱼的伤口修复机制。研究中使用 5mm 皮肤打孔活检针对鱼进行了创伤处理，并将鱼分为两个不同的密度组进行养殖，高密度组（100kg/m）和低密度组（20kg/m），后者作为对照组。对愈合伤口进行了 57 天的跟踪观察，在受伤后第 1、3、7、14、36、43 和 57 天取样。转录组分析表明，高密度鱼类会增强炎症反应，并抑制愈合伤口中的细胞增殖、组织分泌和胶原合成。组织学分析还进一步表明，与对照组相比，高密度组的表皮和真皮修复延迟。治疗还改变了整体伤口收缩。总之，高密度鱼类会增强免疫反应并延迟组织修复，最终导致伤口愈合延迟。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5765/6237775/1e0f66d84972/41598_2018_35002_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5765/6237775/b7d014056617/41598_2018_35002_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5765/6237775/06a24033ab66/41598_2018_35002_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5765/6237775/ee6a7d6663c6/41598_2018_35002_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5765/6237775/dab666386a61/41598_2018_35002_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5765/6237775/23a42b95ad2c/41598_2018_35002_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5765/6237775/57f2de0f6013/41598_2018_35002_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5765/6237775/8e51a38b1ed3/41598_2018_35002_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5765/6237775/83b0e7017302/41598_2018_35002_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5765/6237775/ce905952c8cf/41598_2018_35002_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5765/6237775/b9e8bd21bf72/41598_2018_35002_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5765/6237775/1e0f66d84972/41598_2018_35002_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5765/6237775/b7d014056617/41598_2018_35002_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5765/6237775/06a24033ab66/41598_2018_35002_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5765/6237775/ee6a7d6663c6/41598_2018_35002_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5765/6237775/dab666386a61/41598_2018_35002_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5765/6237775/23a42b95ad2c/41598_2018_35002_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5765/6237775/57f2de0f6013/41598_2018_35002_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5765/6237775/8e51a38b1ed3/41598_2018_35002_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5765/6237775/83b0e7017302/41598_2018_35002_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5765/6237775/ce905952c8cf/41598_2018_35002_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5765/6237775/b9e8bd21bf72/41598_2018_35002_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5765/6237775/1e0f66d84972/41598_2018_35002_Fig11_HTML.jpg

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[6]
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[7]
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[8]
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[9]
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本文引用的文献

[1]
Genome-wide analysis of Atlantic salmon (Salmo salar) mucin genes and their role as biomarkers.

PLoS One. 2017-12-13

[2]
Effect of asiaticoside on the healing of skin wounds in the carp Cirrhinus mrigala: An immunohistochemical investigation.

Tissue Cell. 2017-12

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Adv Drug Deliv Rev. 2017-9-29

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Silver nanoparticles enhance wound healing in zebrafish (Danio rerio).

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Effect of temperature and diet on wound healing in Atlantic salmon (Salmo salar L.).

Fish Physiol Biochem. 2015-12

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Matrix metalloproteinase 9 modulates collagen matrices and wound repair.

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Metalloproteinases and Wound Healing.

Adv Wound Care (New Rochelle). 2015-4-1

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Matrix Biol. 2015-3-11

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