Design of Potent Inhibitors for Human Brain Memapsin 2 (-Secretase).
作者信息
Ghosh Arun K, Shin Dongwoo, Downs Debbie, Koelsch Gerald, Lin Xinli, Ermolieff Jacques, Tang Jordan
机构信息
Department of Chemistry, UniVersity of Illinois at Chicago, Chicago, Illinois.
Protein Studies Program, Oklahoma Medical Research Foundation and Department of Biochemistry and Molecular Biology, UniVersity of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104.
出版信息
J Am Chem Soc. 2000 Apr 12;122(14):3522-3523. doi: 10.1021/ja000300g. Epub 2000 Mar 23.
Abstract
摘要
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本文引用的文献
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Transition-State Mimetics for HIV Protease Inhibitors: Stereocontrolled Synthesis of Hydroxyethylene and Hydroxyethylamine Isosteres by Ester-Derived Titanium Enolate Syn and Anti-Aldol Reactions.用于HIV蛋白酶抑制剂的过渡态模拟物：通过酯衍生的钛烯醇盐顺式和反式羟醛缩合反应立体控制合成羟乙烯和羟乙胺电子等排体
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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein.人天冬氨酸蛋白酶膜内天冬氨酸蛋白酶2切割β-淀粉样前体蛋白的β-分泌酶位点。
Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1456-60. doi: 10.1073/pnas.97.4.1456.
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Identification of a novel aspartic protease (Asp 2) as beta-secretase.鉴定一种新型天冬氨酸蛋白酶（Asp 2）作为β-分泌酶。
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Purification and cloning of amyloid precursor protein beta-secretase from human brain.从人脑中纯化及克隆淀粉样前体蛋白β-分泌酶
Nature. 1999 Dec 2;402(6761):537-40. doi: 10.1038/990114.
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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.具有阿尔茨海默病β-分泌酶活性的膜锚定天冬氨酰蛋白酶。
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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.跨膜天冬氨酸蛋白酶BACE对阿尔茨海默病淀粉样前体蛋白的β-分泌酶切割。
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The penetration of anti-infectives into the central nervous system.抗感染药物在中枢神经系统中的渗透。
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Cellular mechanisms of beta-amyloid production and secretion.β-淀粉样蛋白产生与分泌的细胞机制。
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Design of tight-binding human immunodeficiency virus type 1 protease inhibitors.人免疫缺陷病毒1型蛋白酶紧密结合抑制剂的设计
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