Kriegner Helene, Weil Matthias, Jones Matthew J
Institute for Chemical Technologies and Analytics, Division of Structural Chemistry, TU Wien, Getreidemarkt 9/164-SC, A-1060 Vienna, Austria.
Patheon Austria GmbH & Co KG, St.-Peter-Strasse 25, A-4020 Linz, Austria.
Acta Crystallogr E Crystallogr Commun. 2018 Oct 19;74(Pt 11):1624-1627. doi: 10.1107/S2056989018014652. eCollection 2018 Nov 1.
The asymmetric unit of the methanol solvate of sodium naproxen, systematic name: sodium (2)-2-(6-meth-oxy-naphthalen-2-yl)propano-ate methanol sesquisolvate, Na·CHO ·1.5CHOH, comprises two formula units of the mol-ecular salt and three methanol mol-ecules. One of the sodium cations exhibits a coordination number of six and is bonded to three carboxyl-ate O atoms and three methanol OH groups whereas the second sodium cation has a coordination number of seven, defined by five carboxyl-ate O atoms and two methanol OH groups. Both coordination polyhedra around the sodium cations are considerably distorted. The two types of cations are bridged into polymeric chains extending parallel to [010]. This arrangement is stabilized by intrachain O-H⋯O hydrogen bonds between methanol ligands as donor and carboxyl-ate O atoms as acceptor groups. The hydro-phobic 6-meth-oxy-naphthyl moieties flank the hydro-philic sodium oxygen chains into ribbons parallel to [010]. There are no noticeable inter-molecular inter-actions between these ribbons. One of the 6-meth-oxy-naphthyl moieties is disordered over two sets of sites in a 0.723 (3):0.277 (3) ratio.
萘普生钠甲醇溶剂化物的不对称单元，系统名称为：（2）-2-（6-甲氧基萘-2-基）丙酸钠甲醇倍半溶剂化物，Na·C₁₄H₁₄O₃·1.5CH₃OH，包含两个分子盐的化学式单元和三个甲醇分子。其中一个钠离子的配位数为6，与三个羧酸根O原子和三个甲醇OH基团键合，而第二个钠离子的配位数为7，由五个羧酸根O原子和两个甲醇OH基团定义。钠离子周围的两个配位多面体都有相当大的畸变。这两种类型的阳离子桥连形成平行于[010]延伸的聚合物链。这种排列通过甲醇配体作为供体和羧酸根O原子作为受体基团之间的链内O-H⋯O氢键得以稳定。疏水的6-甲氧基萘基部分沿着亲水性的钠氧链排列成平行于[010]的条带。这些条带之间没有明显的分子间相互作用。其中一个6-甲氧基萘基部分在两组位置上无序，比例为0.723 (3):0.277 (3)。
