探索2,4,6-三氯-1,3,5-三嗪（TCT）作为与不同亲核试剂的三功能连接体的正交化学选择性：游戏规则
Exploring the Orthogonal Chemoselectivity of 2,4,6-Trichloro-1,3,5-Triazine (TCT) as a Trifunctional Linker With Different Nucleophiles: Rules of the Game.
作者信息
Sharma Anamika, El-Faham Ayman, de la Torre Beatriz G, Albericio Fernando
机构信息
KRISP, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa.
出版信息
Front Chem. 2018 Nov 1;6:516. doi: 10.3389/fchem.2018.00516. eCollection 2018.
The study involves exploring the three orthogonal sites for aromatic nucleophilic substitution in cyanuric chloride (TCT). The preferential order of incorporation of different nucleophiles (such as alcohol, thiol, and amine) was addressed both experimentally and theoretically. The preferential order for incorporating nucleophiles in TCT was found to be alcohol > thiol > amine.
该研究涉及探索三聚氯氰（TCT）中芳香亲核取代的三个正交位点。通过实验和理论方法研究了不同亲核试剂（如醇、硫醇和胺）的引入优先顺序。结果发现，在TCT中引入亲核试剂的优先顺序为醇＞硫醇＞胺。
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