Department of Onco-Hematology, Azienda Ospedaliera 'Ospedali Riuniti Marche Nord', 61122 Pesaro, Italy.
Oncology Radiodiagnostics, Oncology Institute of Veneto, Institute for the Research & Treatment of Cancer (IRCC), 35128 Padova, Italy.
Future Oncol. 2019 Mar;15(7):695-703. doi: 10.2217/fon-2018-0425. Epub 2018 Nov 16.
Transarterial chemoembolization (TACE) is indicated in unresectable hepatocellular carcinoma and allows the delivery of embolics inside tumor vascularization to reduce blood supply and release gradually the drug. This lowers the systemic exposure to chemotherapeutics, while increasing their local concentration and tissue necrosis that is higher than conventional TACE. The technology of TACE has seen the introduction of several types of embolics that are made of different materials. Available embolics for TACE include: drug-eluting beads (DC beads), acrylic copolymer, tris-acrylic microspheres and polyethylene glycol (PEG) microspheres. Few studies are available on PEG embolics and their use for TACE. This review focuses on the efficacy and safety of TACE performed with PEG microspheres for the treatment of hepatocellular carcinoma and discusses future therapeutic advantages.
经动脉化疗栓塞术（TACE）适用于不可切除的肝细胞癌，可以将栓塞剂输送到肿瘤血管内，以减少血液供应并逐渐释放药物。这降低了化疗药物的全身暴露，同时增加了其局部浓度和组织坏死，高于传统的 TACE。TACE 技术已经引入了几种不同材料制成的栓塞剂。可用于 TACE 的栓塞剂包括：载药微球（DC 微球）、丙烯酸共聚物、三丙烯酸微球和聚乙二醇（PEG）微球。PEG 栓塞剂的相关研究较少，其在 TACE 中的应用也较少。本综述重点介绍了使用 PEG 微球进行 TACE 治疗肝细胞癌的疗效和安全性，并讨论了未来的治疗优势。
