Bertoni Serena, Dolci Luisa S, Albertini Beatrice, Passerini Nadia
Department of Pharmacy & Biotechnology, University of Bologna, Via S Donato 19/2, 40127 Bologna, Italy.
Ther Deliv. 2018 Nov;9(11):833-845. doi: 10.4155/tde-2018-0049.
Spray congealing is a low cost, simple and versatile method to produce microparticles without the use of organic or aqueous solvent. This review provides a detailed picture of the pharmaceutical applications of this technology, with an overview of the spray-congealed-based drug-delivery systems. First, the basic principles and equipment of spray congealing technology are presented. Then, representative examples of the drug-delivery systems are examined and critically discussed. Emphasis is given on the role of formulation variables, together with practical considerations for formulation design. In addition, the current status of the industrial applications of this technology within the pharmaceutical field is examined. The final part points out benefits, limitations and future perspectives of this technology in drug delivery.
喷雾冷凝是一种低成本、简单且通用的制备微粒的方法，无需使用有机溶剂或水性溶剂。本综述详细介绍了该技术在制药领域的应用情况，并概述了基于喷雾冷凝的药物递送系统。首先，介绍了喷雾冷凝技术的基本原理和设备。然后，对药物递送系统的代表性实例进行了研究和批判性讨论。重点阐述了制剂变量的作用以及制剂设计的实际考量因素。此外，还考察了该技术在制药领域的工业应用现状。最后一部分指出了该技术在药物递送方面的优势、局限性及未来前景。
